A global benchmark study using affinity-based biosensors
Rebecca L. Rich
(1)
,
Giuseppe A. Papalia
(1)
,
Peter J. Flynn
(2)
,
Jamie Furneisen
(3)
,
John Quinn
(4)
,
Joshua S. Klein
(5)
,
Phini S. Katsamba
(6)
,
M. Brent Waddell
(7)
,
Michael Scott
(8)
,
Joshua Thompson
(9)
,
Judie Berlier
(9)
,
Schuyler Corry
(9)
,
Mireille Baltzinger
(10)
,
Gabrielle Zeder-Lutzi
(10)
,
Andreas Schoenemann
(11)
,
Anca Clabbers
(12)
,
Sébastien Wieckowski
(13)
,
Mary M. Murphy
(14)
,
Phillip Page
(14)
,
Thomas E. Ryan
(14)
,
Jay Duffner
(15)
,
Tanmoy Ganguly
(15)
,
John Corbin
(16)
,
Satyen Gautam
(17)
,
Gregor Anderluh
(18)
,
Andrej Bavdek
(18)
,
Dana Reichmann
(19)
,
Satya P. Yadav
(20)
,
Eric Hommema
(21)
,
Ewa Pol
(22)
,
Andrew Drake
(23)
,
Scott Klakamp
(23)
,
Trevor Chapman
(24)
,
Dawn Kernaghan
(25)
,
Ken Miller
(25)
,
Jason Schuman
(26)
,
Kevin Lindquist
(26)
,
Kara Herlihy
(26)
,
Michael B. Murphy
(26)
,
Richard Bohnsack
(27)
,
Bruce Andrien
(28)
,
Pietro Brandani
(29)
,
Danny Terwey
(30)
,
Rohn Millican
(31)
,
Ryan J. Darling
(31)
,
Liann Wang
(31)
,
Quincy Carter
(31)
,
Joe Dotzlaf
(31)
,
Jacinto Lopez-Sagaseta
(32)
,
Islay Campbell
(33)
,
Paola Torreri
(34)
,
Sylviane Hoos
(35)
,
Patrick England
(35)
,
Yang Liu
(36)
,
Yasmina Abdiche
(37)
,
Daniel Malashock
(37)
,
Alanna Pinkerton
(37)
,
Melanie Wong
(38)
,
Eileen Lafer
(39)
,
Cynthia Hinck
(39)
,
Kevin Thompson
(40)
,
Carmelo Di Primo
(41)
,
Alison Joyce
(42)
,
Jonathan Brooks
(42)
,
Federico Torta
(43)
,
Anne Birgitte Bagge Hagel
(44)
,
Janus Krarup
(44)
,
Jesper Pass
(44)
,
Monica Ferreira
(45)
,
Sergei Shikov
(46)
,
Malgorzata Mikolajczyk
(47)
,
Yuki Abe
(48)
,
Gaetano Barbato
(49)
,
Anthony M. Giannetti
(50)
,
Ganeshram Krishnamoorthy
(51)
,
Bianca Beusink
(51)
,
Daulet Satpaev
(52)
,
Tiffany Tsang
(53)
,
Eric Fang
(53)
,
James Partridge
(54)
,
Stephen Brohawn
(54)
,
James Horn
(55)
,
Otto Pritsch
(56)
,
Gonzalo Obal
(56)
,
Sanjay Nilapwar
(57)
,
Ben Busby
(58)
,
Gerardo Gutierrez-Sanchez
(59)
,
Ruchira das Gupta
(60)
,
Sylvie Canepa
(61)
,
Krista Witte
(62)
,
Zaneta Nikolovska-Coleska
(63)
,
Yun Hee Cho
(64)
,
Roberta d'Agata
(65)
,
Kristian Schlick
(66)
,
Rosy Calvert
(67)
,
Eva M. Munoz
(68)
,
Maria Jose Hernaiz
(68)
,
Tsafir Bravman
(69)
,
Monica Dines
(69)
,
Min-Hsiang Yang
(70)
,
Agnes Puskas
(71)
,
Erica Boni
(72)
,
Jiejin Li
(73)
,
Martin Wear
(74)
,
Asya Grinberg
(75)
,
Jason Baardsnes
(76)
,
Olan Dolezal
(77)
,
Melicia Gainey
(78)
,
Henrik Anderson
(79)
,
Jinlin Peng
(80)
,
Mark Lewis
(80)
,
Peter Spies
(81)
,
Quyhn Trinh
(82)
,
Sergei Bibikov
(82)
,
Jill Raymond
(82)
,
Mohammed Yousef
(82)
,
Vidya Chandrasekaran
(82)
,
Yuguo Feng
(82)
,
Anne Emerick
(82)
,
Suparna Mundodo
(82)
,
Rejane Guimaraes
(82)
,
Katy Mcgirr
(82)
,
Yue-Ji Li
(83)
,
Heather Hughes
(84)
,
Hubert Mantz
(85)
,
Rostislav Skrabana
(86)
,
Mark Witmer
(87)
,
Joshua Ballard
(88)
,
Loïc M Martin
(89)
,
Petr Skladal
(90)
,
George Korza
(91)
,
Ite Laird-Offringa
(92)
,
Charlene S. Lee
(92)
,
Abdelkrim Khadir
(93)
,
Frank Podlaski
(94)
,
Phillippe Neuner
(95)
,
Julie Rothacker
(96)
,
Ashique Rafique
(97)
,
Nico Dankbar
(98)
,
Peter Kainz
(99)
,
Erk Gedig
(100)
,
Momchilo Vuyisich
(101)
,
Christina Boozer
(102)
,
Nguyen Ly
(103)
,
Mark Toews
(104)
,
Aykut Uren
(105)
,
Oleksandr Kalyuzhniy
(106)
,
Kenneth Lewis
(107)
,
Eugene Chomey
(108)
,
Brian J. Pak
(109)
,
David G. Myszka
(1)
1
School of Medicine [University of Utah, Salt Lake City]
2 KaloBios Pharmaceuticals [San Francisco]
3 Schering–Plough Biopharma [Palo Alto]
4 Nomadics [Oklahoma City]
5 Biochemistry and Molecular Biophysics [Pasadena]
6 Department of Biochemistry and Molecular Biophysics
7 Hartwell Center for Bioinformatics and Biotechnology [Memphis]
8 UZH - Universität Zürich [Zürich] = University of Zurich
9 Molecular Probes/Invitrogen [Eugene]
10 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
11 MerckKGaA
12 Abbott Bioresearch Center [Worcester]
13 Institut de biologie cellulaire et moléculaire [Strasbourg]
14 Reichert [Depew}
15 Momenta Pharmaceuticals [Cambridge]
16 XOMA (U.S.)
17 Department of Chemical and Biomolecular Engineering, National University of Singapore
18 Department of Biology [Ljubljiana]
19 Weizmann Institute of Science - Department of Biological Chemistry
20 Molecular Biotechnology Core Laboratory [Cleveland]
21 ThermoFisher Scientific [Rockford]
22 Biacore/GE Healthcare [Uppsala]
23 AstraZeneca [Hayward]
24 Neurodegeneration Research Department [Harlow]
25 MedImmune
26 Biacore/GE Healthcare [Piscataway]
27 Department of Biochemistry [Milwaukee]
28 Alexion Pharmaceuticals [Cheshire]
29 Applied Biosystems [Foster City]
30 diaDexus [South San Francisco]
31 Eli Lilly and Company [Indianapolis]
32 CIMA - Center for Applied Medical Research [Plamplona]
33 EMD Lexigen Research Center [Billerica]
34 Department of Cell Biology and Neuroscience [Rome]
35 Département de Biologie structurale et Chimie - Department of Structural Biology and Chemistry
36 Department of Chemistry [Atlanta]
37 Pfizer/Rinat Laboratories [South San Francisco]
38 PDLBioPharma [Fremont]
39 Department of Biochemistry [San Antonio]
40 Akubio [Cambridge]
41 ARN : régulations naturelle et artificielle
42 Wyeth Research [Cambridge]
43 Department of Biochemistry and Molecular Biology [Odense]
44 NovoNordisk [Gentofte]
45 Södertörns University College [Huddinge]
46 Department of Biochemistry [Philadelphia]
47 FDA - U.S. Food and Drug Administration
48 Department of Biochemical Engineering [London]
49 Merck [Rome]
50 Roche [Palo Alto]
51 University of Twente
52 Agensys [Santa Monica]
53 Novartis [Emeryville]
54 MIT - Massachusetts Institute of Technology
55 Northern Illinois University
56 Institut Pasteur de Montevideo
57 University of Manchester [Manchester]
58 Department of Physiology [Baltimore]
59 Complex Carbohydrate Research Center [Athens, GA, USA]
60 Adnexus Therapeutics [Waltham}
61 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
62 ForteBio [Menlo Park]
63 University of Michigan [Ann Arbor]
64 Human Genome Sciences [Rockville]
65 Department of Chemical Sciences [Catania]
66 MSU - Montana State University
67 GKT School of Biomedical Sciences [London]
68 Organic and Pharmaceutical Chemistry Department [Madrid]
69 Bio-Rad Haifa
70 Institute of Chemistry [Taipei]
71 Department of Microbiology and Molecular Genetics
72 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
73 Division of Molecular Structure [London]
74 Centre for Translational and Chemical Biology, Institute of Structural and Molecular Biology [Edinburgh]
75 Acceleron Pharma [Cambridge]
76 Biotechnology Research Institute [Montreal]
77 CSIRO Health Sciences and Nutrition [Parkville]
78 Battelle Biomedical Research Center [Columbus]
79 Attana AB [Stockholm]
80 Corning Incorporated
81 School of Life Sciences, Institute for Chemistry and Bioanalytics [Muttenz]
82 Bio-Rad [Hercules]
83 Monsanto [Chesterfield]
84 Genzyme [Cambridge]
85 Saarland University [Saarbrücken]
86 Institute of Neuroimmunology of SAS [Bratislava]
87 Bristol-Myers Squibb [Princeton]
88 Array Biopharma [Boulder]
89 SIMoS - Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO)
90 MUNI - Masaryk University [Brno]
91 University of Connecticut Health Center [Farmington]
92 USC - University of Southern California
93 GeminX Biotechnologies [Montreal]
94 Hoffman–La Roche [Nutley]
95 IRBM, Pomezia [Rome]
96 Ludwig Institute for Cancer Research
97 Regeneron Pharmaceuticals [Tarrytown, NY]
98 University of Muenster
99 Department of Molecular Biology [Salzburg]
100 XanTec Bioanalytics [Muenster]
101 Biosciences Division [Los Alamos]
102 Lumera [Bothell]
103 ASU - Arizona State University [Tempe]
104 Dyax [Cambridge]
105 Lombardi Comprehensive Cancer Center
106 Department of Biochemistry [Seattle]
107 ZymoGenetics
108 Bio-Rad Canada [Edmonton]
109 Bio-Rad Canada [Toronto]
2 KaloBios Pharmaceuticals [San Francisco]
3 Schering–Plough Biopharma [Palo Alto]
4 Nomadics [Oklahoma City]
5 Biochemistry and Molecular Biophysics [Pasadena]
6 Department of Biochemistry and Molecular Biophysics
7 Hartwell Center for Bioinformatics and Biotechnology [Memphis]
8 UZH - Universität Zürich [Zürich] = University of Zurich
9 Molecular Probes/Invitrogen [Eugene]
10 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
11 MerckKGaA
12 Abbott Bioresearch Center [Worcester]
13 Institut de biologie cellulaire et moléculaire [Strasbourg]
14 Reichert [Depew}
15 Momenta Pharmaceuticals [Cambridge]
16 XOMA (U.S.)
17 Department of Chemical and Biomolecular Engineering, National University of Singapore
18 Department of Biology [Ljubljiana]
19 Weizmann Institute of Science - Department of Biological Chemistry
20 Molecular Biotechnology Core Laboratory [Cleveland]
21 ThermoFisher Scientific [Rockford]
22 Biacore/GE Healthcare [Uppsala]
23 AstraZeneca [Hayward]
24 Neurodegeneration Research Department [Harlow]
25 MedImmune
26 Biacore/GE Healthcare [Piscataway]
27 Department of Biochemistry [Milwaukee]
28 Alexion Pharmaceuticals [Cheshire]
29 Applied Biosystems [Foster City]
30 diaDexus [South San Francisco]
31 Eli Lilly and Company [Indianapolis]
32 CIMA - Center for Applied Medical Research [Plamplona]
33 EMD Lexigen Research Center [Billerica]
34 Department of Cell Biology and Neuroscience [Rome]
35 Département de Biologie structurale et Chimie - Department of Structural Biology and Chemistry
36 Department of Chemistry [Atlanta]
37 Pfizer/Rinat Laboratories [South San Francisco]
38 PDLBioPharma [Fremont]
39 Department of Biochemistry [San Antonio]
40 Akubio [Cambridge]
41 ARN : régulations naturelle et artificielle
42 Wyeth Research [Cambridge]
43 Department of Biochemistry and Molecular Biology [Odense]
44 NovoNordisk [Gentofte]
45 Södertörns University College [Huddinge]
46 Department of Biochemistry [Philadelphia]
47 FDA - U.S. Food and Drug Administration
48 Department of Biochemical Engineering [London]
49 Merck [Rome]
50 Roche [Palo Alto]
51 University of Twente
52 Agensys [Santa Monica]
53 Novartis [Emeryville]
54 MIT - Massachusetts Institute of Technology
55 Northern Illinois University
56 Institut Pasteur de Montevideo
57 University of Manchester [Manchester]
58 Department of Physiology [Baltimore]
59 Complex Carbohydrate Research Center [Athens, GA, USA]
60 Adnexus Therapeutics [Waltham}
61 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
62 ForteBio [Menlo Park]
63 University of Michigan [Ann Arbor]
64 Human Genome Sciences [Rockville]
65 Department of Chemical Sciences [Catania]
66 MSU - Montana State University
67 GKT School of Biomedical Sciences [London]
68 Organic and Pharmaceutical Chemistry Department [Madrid]
69 Bio-Rad Haifa
70 Institute of Chemistry [Taipei]
71 Department of Microbiology and Molecular Genetics
72 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
73 Division of Molecular Structure [London]
74 Centre for Translational and Chemical Biology, Institute of Structural and Molecular Biology [Edinburgh]
75 Acceleron Pharma [Cambridge]
76 Biotechnology Research Institute [Montreal]
77 CSIRO Health Sciences and Nutrition [Parkville]
78 Battelle Biomedical Research Center [Columbus]
79 Attana AB [Stockholm]
80 Corning Incorporated
81 School of Life Sciences, Institute for Chemistry and Bioanalytics [Muttenz]
82 Bio-Rad [Hercules]
83 Monsanto [Chesterfield]
84 Genzyme [Cambridge]
85 Saarland University [Saarbrücken]
86 Institute of Neuroimmunology of SAS [Bratislava]
87 Bristol-Myers Squibb [Princeton]
88 Array Biopharma [Boulder]
89 SIMoS - Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO)
90 MUNI - Masaryk University [Brno]
91 University of Connecticut Health Center [Farmington]
92 USC - University of Southern California
93 GeminX Biotechnologies [Montreal]
94 Hoffman–La Roche [Nutley]
95 IRBM, Pomezia [Rome]
96 Ludwig Institute for Cancer Research
97 Regeneron Pharmaceuticals [Tarrytown, NY]
98 University of Muenster
99 Department of Molecular Biology [Salzburg]
100 XanTec Bioanalytics [Muenster]
101 Biosciences Division [Los Alamos]
102 Lumera [Bothell]
103 ASU - Arizona State University [Tempe]
104 Dyax [Cambridge]
105 Lombardi Comprehensive Cancer Center
106 Department of Biochemistry [Seattle]
107 ZymoGenetics
108 Bio-Rad Canada [Edmonton]
109 Bio-Rad Canada [Toronto]
Sylviane Hoos
- Fonction : Auteur
- PersonId : 747020
- IdHAL : sylviane-hoos
- ORCID : 0000-0002-4029-562X
Patrick England
- Fonction : Auteur
- PersonId : 735030
- IdHAL : patrick-england
- ORCID : 0000-0001-6410-5918
Carmelo Di Primo
- Fonction : Auteur
- PersonId : 772950
- ORCID : 0000-0002-0509-8399
- IdRef : 071086579
Loïc M Martin
- Fonction : Auteur
- PersonId : 740796
- IdHAL : loic-mjc-martin
- ORCID : 0000-0002-7940-2955
- IdRef : 169807029
Résumé
To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used. (C) 2008 Elsevier Inc. All rights reserved.
Domaines
Médecine humaine et pathologieFormat du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used. (C) 2008 Elsevier Inc. All rights reserved.
|
Titre |
en
A global benchmark study using affinity-based biosensors
|
Auteur(s) |
Rebecca L. Rich
1
, Giuseppe A. Papalia
1
, Peter J. Flynn
2
, Jamie Furneisen
3
, John Quinn
4
, Joshua S. Klein
5
, Phini S. Katsamba
6
, M. Brent Waddell
7
, Michael Scott
8
, Joshua Thompson
9
, Judie Berlier
9
, Schuyler Corry
9
, Mireille Baltzinger
10
, Gabrielle Zeder-Lutzi
10
, Andreas Schoenemann
11
, Anca Clabbers
12
, Sébastien Wieckowski
13
, Mary M. Murphy
14
, Phillip Page
14
, Thomas E. Ryan
14
, Jay Duffner
15
, Tanmoy Ganguly
15
, John Corbin
16
, Satyen Gautam
17
, Gregor Anderluh
18
, Andrej Bavdek
18
, Dana Reichmann
19
, Satya P. Yadav
20
, Eric Hommema
21
, Ewa Pol
22
, Andrew Drake
23
, Scott Klakamp
23
, Trevor Chapman
24
, Dawn Kernaghan
25
, Ken Miller
25
, Jason Schuman
26
, Kevin Lindquist
26
, Kara Herlihy
26
, Michael B. Murphy
26
, Richard Bohnsack
27
, Bruce Andrien
28
, Pietro Brandani
29
, Danny Terwey
30
, Rohn Millican
31
, Ryan J. Darling
31
, Liann Wang
31
, Quincy Carter
31
, Joe Dotzlaf
31
, Jacinto Lopez-Sagaseta
32
, Islay Campbell
33
, Paola Torreri
34
, Sylviane Hoos
35
, Patrick England
35
, Yang Liu
36
, Yasmina Abdiche
37
, Daniel Malashock
37
, Alanna Pinkerton
37
, Melanie Wong
38
, Eileen Lafer
39
, Cynthia Hinck
39
, Kevin Thompson
40
, Carmelo Di Primo
41
, Alison Joyce
42
, Jonathan Brooks
42
, Federico Torta
43
, Anne Birgitte Bagge Hagel
44
, Janus Krarup
44
, Jesper Pass
44
, Monica Ferreira
45
, Sergei Shikov
46
, Malgorzata Mikolajczyk
47
, Yuki Abe
48
, Gaetano Barbato
49
, Anthony M. Giannetti
50
, Ganeshram Krishnamoorthy
51
, Bianca Beusink
51
, Daulet Satpaev
52
, Tiffany Tsang
53
, Eric Fang
53
, James Partridge
54
, Stephen Brohawn
54
, James Horn
55
, Otto Pritsch
56
, Gonzalo Obal
56
, Sanjay Nilapwar
57
, Ben Busby
58
, Gerardo Gutierrez-Sanchez
59
, Ruchira das Gupta
60
, Sylvie Canepa
61
, Krista Witte
62
, Zaneta Nikolovska-Coleska
63
, Yun Hee Cho
64
, Roberta d'Agata
65
, Kristian Schlick
66
, Rosy Calvert
67
, Eva M. Munoz
68
, Maria Jose Hernaiz
68
, Tsafir Bravman
69
, Monica Dines
69
, Min-Hsiang Yang
70
, Agnes Puskas
71
, Erica Boni
72
, Jiejin Li
73
, Martin Wear
74
, Asya Grinberg
75
, Jason Baardsnes
76
, Olan Dolezal
77
, Melicia Gainey
78
, Henrik Anderson
79
, Jinlin Peng
80
, Mark Lewis
80
, Peter Spies
81
, Quyhn Trinh
82
, Sergei Bibikov
82
, Jill Raymond
82
, Mohammed Yousef
82
, Vidya Chandrasekaran
82
, Yuguo Feng
82
, Anne Emerick
82
, Suparna Mundodo
82
, Rejane Guimaraes
82
, Katy Mcgirr
82
, Yue-Ji Li
83
, Heather Hughes
84
, Hubert Mantz
85
, Rostislav Skrabana
86
, Mark Witmer
87
, Joshua Ballard
88
, Loïc M Martin
89
, Petr Skladal
90
, George Korza
91
, Ite Laird-Offringa
92
, Charlene S. Lee
92
, Abdelkrim Khadir
93
, Frank Podlaski
94
, Phillippe Neuner
95
, Julie Rothacker
96
, Ashique Rafique
97
, Nico Dankbar
98
, Peter Kainz
99
, Erk Gedig
100
, Momchilo Vuyisich
101
, Christina Boozer
102
, Nguyen Ly
103
, Mark Toews
104
, Aykut Uren
105
, Oleksandr Kalyuzhniy
106
, Kenneth Lewis
107
, Eugene Chomey
108
, Brian J. Pak
109
, David G. Myszka
1
1
School of Medicine [University of Utah, Salt Lake City]
( 329105 )
- 30 N. 1900 E.
Salt Lake City, UT 84132
- États-Unis
2
KaloBios Pharmaceuticals [San Francisco]
( 572455 )
- KaloBios Pharmaceuticals, South San Francisco, CA 94080, USA
- États-Unis
3
Schering–Plough Biopharma [Palo Alto]
( 572456 )
- Palo Alto, CA 94304, USA
- États-Unis
4
Nomadics [Oklahoma City]
( 572457 )
- Oklahoma City, OK 73104,USA
- États-Unis
5
Biochemistry and Molecular Biophysics [Pasadena]
( 572458 )
- California Institute of Technology, Pasadena, CA91125, USA
- États-Unis
6
Department of Biochemistry and Molecular Biophysics
( 161340 )
- New York, NY 10032
- États-Unis
7
Hartwell Center for Bioinformatics and Biotechnology [Memphis]
( 572460 )
- Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
- États-Unis
8
UZH -
Universität Zürich [Zürich] = University of Zurich
( 146992 )
- Rämistrasse 71 CH-8006 Zürich
- Suisse
9
Molecular Probes/Invitrogen [Eugene]
( 572461 )
- Eugene, OR 97402, USA
- États-Unis
10
IGBMC -
Institut de génétique et biologie moléculaire et cellulaire
( 1047 )
- I.G.B.M.C, Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 ILLKIRCH CEDEX
- France
11
MerckKGaA
( 73237 )
- Frankfurter Str. 250 64293 Darmstadt
- Allemagne
12
Abbott Bioresearch Center [Worcester]
( 572462 )
- Worcester, MA01605, USA
- États-Unis
13
Institut de biologie cellulaire et moléculaire [Strasbourg]
( 572463 )
- Université de Strasbourg, 67084 Strasbourg, France
- France
14
Reichert [Depew}
( 572464 )
- Depew, NY 14043, USA
- États-Unis
15
Momenta Pharmaceuticals [Cambridge]
( 572465 )
- Cambridge,MA 02142, USA
- États-Unis
16
XOMA (U.S.)
( 572466 )
- Emeryville, CA 94608, USA
- États-Unis
17
Department of Chemical and Biomolecular Engineering, National University of Singapore
( 546925 )
- 4 Engineering Drive 4
- Singapour
18
Department of Biology [Ljubljiana]
( 572454 )
- Slovénie
19
Weizmann Institute of Science -
Department of Biological Chemistry
( 103401 )
- 3Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100
- Israël
20
Molecular Biotechnology Core Laboratory [Cleveland]
( 572468 )
- Cleveland Clinic Foundation, Cleveland, OH 44195, USA
- États-Unis
21
ThermoFisher Scientific [Rockford]
( 572469 )
- Rockford, IL 61101, USA
- États-Unis
22
Biacore/GE Healthcare [Uppsala]
( 572470 )
- SE-754 50 Uppsala,Sweden
- Suède
23
AstraZeneca [Hayward]
( 572471 )
- Hayward, CA 94545, USA
- États-Unis
24
Neurodegeneration Research Department [Harlow]
( 572473 )
- GlaxoSmithKline, Harlow CM19 5AW, UK
- Royaume-Uni
25
MedImmune
( 471932 )
- Gaithersburg, MD
- États-Unis
26
Biacore/GE Healthcare [Piscataway]
( 572474 )
- Piscataway, NJ 08854, USA
- États-Unis
27
Department of Biochemistry [Milwaukee]
( 572476 )
- Medical College of Wisconsin, Milwaukee, WI 53226, USA
- États-Unis
28
Alexion Pharmaceuticals [Cheshire]
( 572477 )
- Alexion Pharmaceuticals, Cheshire, CT 06410, USA
- États-Unis
29
Applied Biosystems [Foster City]
( 572478 )
- Applied Biosystems, Foster City, CA 94404, USA
- États-Unis
30
diaDexus [South San Francisco]
( 572479 )
- diaDexus, South San Francisco, CA 94080,USA
- États-Unis
31
Eli Lilly and Company [Indianapolis]
( 563590 )
- États-Unis
32
CIMA -
Center for Applied Medical Research [Plamplona]
( 169379 )
- Pamplona
- Espagne
33
EMD Lexigen Research Center [Billerica]
( 572480 )
- EMD LexigenResearch Center, Billerica, MA 01821, USA
- États-Unis
34
Department of Cell Biology and Neuroscience [Rome]
( 572481 )
- Italie
35
Département de Biologie structurale et Chimie - Department of Structural Biology and Chemistry
( 468085 )
- 25-28 rue du Docteur Roux, 75724 Paris cedex 15
- France
36
Department of Chemistry [Atlanta]
( 572482 )
- Georgia State University, Atlanta, GA 30303, USA
- États-Unis
37
Pfizer/Rinat Laboratories [South San Francisco]
( 572546 )
- South San Francisco, CA 94080, USA
- États-Unis
38
PDLBioPharma [Fremont]
( 572547 )
- Fremont, CA 94555, USA
- États-Unis
39
Department of Biochemistry [San Antonio]
( 572549 )
- Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
- États-Unis
40
Akubio [Cambridge]
( 572550 )
- Cambridge CB4 0GJ, UK
- Royaume-Uni
41
ARN : régulations naturelle et artificielle
( 27741 )
- Universite Victor Segalen 146, rue leo saignat batiment 3a 33076 BORDEAUX CEDEX
- France
42
Wyeth Research [Cambridge]
( 572551 )
- Wyeth Research, Cambridge, MA 02140, USA
- États-Unis
43
Department of Biochemistry and Molecular Biology [Odense]
( 572552 )
- University of Southern Denmark, DK-5230 Odense M, Denmark
- Danemark
44
NovoNordisk [Gentofte]
( 572553 )
- 2820 Gentofte, Denmark
- Danemark
45
Södertörns University College [Huddinge]
( 572554 )
- 14152 Huddinge,Sweden
- Suède
46
Department of Biochemistry [Philadelphia]
( 572555 )
- Temple University, Philadelphia, PA 19140, USA
- États-Unis
47
FDA -
U.S. Food and Drug Administration
( 464537 )
- 10903 New Hampshire Avenue
Silver Spring, MD 20993
- États-Unis
48
Department of Biochemical Engineering [London]
( 572556 )
- University College London, London WC1E 7JE, UK
- Royaume-Uni
49
Merck [Rome]
( 572557 )
- 00040 Rome, Italy
- Italie
50
Roche [Palo Alto]
( 572558 )
- Palo Alto, CA 94304, USA
- États-Unis
51
University of Twente
( 303060 )
- Drienerlolaan 5, 7522 NB Enschede
- Pays-Bas
52
Agensys [Santa Monica]
( 572559 )
- Santa Monica, CA 90404, USA
- États-Unis
53
Novartis [Emeryville]
( 572560 )
- Emeryville, CA 94608, USA
- États-Unis
54
MIT -
Massachusetts Institute of Technology
( 301950 )
- 77 Massachusetts Ave, Cambridge, MA 02139
- États-Unis
55
Northern Illinois University
( 305753 )
- 1425 Lincoln Hwy, DeKalb, IL 60115, États-Unis
- États-Unis
56
Institut Pasteur de Montevideo
( 55924 )
- Mataojo 2020, 11400 Montevideo
- Uruguay
57
University of Manchester [Manchester]
( 121172 )
- Oxford Rd, Manchester M13 9PL
- Royaume-Uni
58
Department of Physiology [Baltimore]
( 572561 )
- University of Maryland, Baltimore, MD 21201, USA
- États-Unis
59
Complex Carbohydrate Research Center [Athens, GA, USA]
( 527635 )
- Athens, GA 30602
- États-Unis
60
Adnexus Therapeutics [Waltham}
( 572562 )
- Waltham, MA 02453,USA
- États-Unis
61
PRC -
Physiologie de la reproduction et des comportements [Nouzilly]
( 199335 )
- Centre de Recherches de Tours 37380 Nouzilly
- France
62
ForteBio [Menlo Park]
( 572563 )
- Menlo Park, CA 94025, USA
- États-Unis
63
University of Michigan [Ann Arbor]
( 24332 )
- 500 Church Street Ann Arbor, MI 48109-1090
- États-Unis
64
Human Genome Sciences [Rockville]
( 572564 )
- Rockville, MD20850, USA
- États-Unis
65
Department of Chemical Sciences [Catania]
( 572565 )
- University of Catania, 95125 Catania, Italy
- Italie
66
MSU -
Montana State University
( 308574 )
- Bozeman, MT 59717
- États-Unis
67
GKT School of Biomedical Sciences [London]
( 572566 )
- London SE1 1UL, UK
- Royaume-Uni
68
Organic and Pharmaceutical Chemistry Department [Madrid]
( 572567 )
- Complutense University, 28040 Madrid, Spain
- Espagne
69
Bio-Rad Haifa
( 572568 )
- 32000 Haifa, Israel
- Israël
70
Institute of Chemistry [Taipei]
( 572569 )
- Academia Sinica, Taipei 115, Taiwan
- Taïwan
71
Department of Microbiology and Molecular Genetics
( 11842 )
- États-Unis
72
FHCRC -
Fred Hutchinson Cancer Research Center [Seattle]
( 41823 )
- 1100 Fairview Ave. N. PO Box 19024 Seattle, WA 98109
- États-Unis
73
Division of Molecular Structure [London]
( 572571 )
- Division of Molecular Structure, National Institute of Medical Research (UK), London NW7 1AA, UK
- Royaume-Uni
74
Centre for Translational and Chemical Biology, Institute of Structural and Molecular Biology [Edinburgh]
( 572572 )
- University of Edinburgh, Edinburgh EH9 3JR, UK
- Royaume-Uni
75
Acceleron Pharma [Cambridge]
( 572573 )
- Acceleron Pharma, Cambridge, MA 02139,USA
- États-Unis
76
Biotechnology Research Institute [Montreal]
( 572574 )
- National Research Council (Canada), Montreal, Que.,Canada H4P 2R2
- Canada
77
CSIRO Health Sciences and Nutrition [Parkville]
( 572575 )
- Parkville, VIC 3052, Australia
- Australie
78
Battelle Biomedical Research Center [Columbus]
( 572576 )
- Columbus, OH 43201, US
- États-Unis
79
Attana AB [Stockholm]
( 572577 )
- SE-113 47 Stockholm, Sweden
- Suède
80
Corning Incorporated
( 1150773 )
- Corning, New York 14831
- États-Unis
81
School of Life Sciences, Institute for Chemistry and Bioanalytics [Muttenz]
( 572579 )
- School of Life Sciences, Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland, CH-4132 Muttenz, Switzerland
- Suisse
82
Bio-Rad [Hercules]
( 572580 )
- Hercules, CA 94547, USA
- États-Unis
83
Monsanto [Chesterfield]
( 572581 )
- Monsanto, Chesterfield, MO 63198, USA
- États-Unis
84
Genzyme [Cambridge]
( 572582 )
- Cambridge, MA 02142, USA
- États-Unis
85
Saarland University [Saarbrücken]
( 110922 )
- 66123 Saarbrücken
- Allemagne
86
Institute of Neuroimmunology of SAS [Bratislava]
( 572583 )
- 84510 Bratislava, Slovakia
- Slovaquie
87
Bristol-Myers Squibb [Princeton]
( 535737 )
- Lawrenceville / Princeton
- États-Unis
88
Array Biopharma [Boulder]
( 572584 )
- Boulder, CO 80301, USA
- États-Unis
89
SIMoS -
Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO)
( 40493 )
- Service d'Ingénierie Moléculaire pour la Santé
(ex SIMOPRO Servce d'ingénierie moléculaire des protéines)
CEA Saclay 91191 Gif sur Yvette cedex
- France
90
MUNI -
Masaryk University [Brno]
( 412450 )
- Kamenice 5, Brno CZ-62500, Czech Republic
- Tchéquie
91
University of Connecticut Health Center [Farmington]
( 572585 )
- Farmington, CT 06030, USA
- États-Unis
92
USC -
University of Southern California
( 301992 )
- Los Angeles, CA, 90089-0484, USA
- États-Unis
93
GeminX Biotechnologies [Montreal]
( 572586 )
- Montreal, Que., Canada H2X 2H7
- Canada
94
Hoffman–La Roche [Nutley]
( 572587 )
- Hoffman–La Roche,Nutley, NJ 07110, USA
- États-Unis
95
IRBM, Pomezia [Rome]
( 572588 )
- IRBM, Pomezia, 00040 Rome, Italy
- Italie
96
Ludwig Institute for Cancer Research
( 500261 )
- 9500 Gilman Drive, La Jolla, CA 92093-0653
- États-Unis
97
Regeneron Pharmaceuticals [Tarrytown, NY]
( 138979 )
- 777 Old Saw Mill River Road Tarrytown, NY 10591
- États-Unis
98
University of Muenster
( 568165 )
- Allemagne
99
Department of Molecular Biology [Salzburg]
( 572589 )
- University of Salzburg, A-5020 Salzburg, Austria
- Autriche
100
XanTec Bioanalytics [Muenster]
( 572590 )
- D-48149 Muenster, Germany
- Allemagne
101
Biosciences Division [Los Alamos]
( 572591 )
- Los Alamos National Laboratory, Los Alamos, NM87545, USA
- États-Unis
102
Lumera [Bothell]
( 572592 )
- Bothell, WA 98011, USA
- États-Unis
103
ASU -
Arizona State University [Tempe]
( 251827 )
- 325 E Apache Blvd, Tempe, AZ 85281, États-Unis
- États-Unis
104
Dyax [Cambridge]
( 572593 )
- Cambridge, MA 02139, USA
- États-Unis
105
Lombardi Comprehensive Cancer Center
( 166461 )
- Washington DC
- États-Unis
106
Department of Biochemistry [Seattle]
( 572594 )
- University of Washington, Seattle, WA 98195, USA
- États-Unis
107
ZymoGenetics
( 323534 )
-
- France
108
Bio-Rad Canada [Edmonton]
( 572595 )
- Edmonton, Alta., Canada T6R 2W6
- Canada
109
Bio-Rad Canada [Toronto]
( 572596 )
- Toronto, Ont., Canada
- Canada
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2009-03-15
|
Langue du document |
Anglais
|
Vulgarisation |
Non
|
Nom de la revue |
|
Volume |
386
|
Page/Identifiant |
194-216
|
Numéro |
2
|
Localisation géographique du document |
UMR 0085 Unité mixte de recherche physiologie de la reproduction et des comportements, Centre de recherche de Tours, 37380 Nouzilly, FRA
|
Public visé |
Scientifique
|
Domaine(s) |
|
Indexation contrôlée |
|
Mots-clés |
en
Kinetics, Biacore, Optical biosensor, Surface plasmon resonance
|
DOI | 10.1016/j.ab.2008.11.021 |
ProdINRA | 27332 |
Pubmed Id | 19133223 |
UT key WOS | 000263789500009 |
Origine :
Fichiers produits par l'(les) auteur(s)
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