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Communication Dans Un Congrès Année : 2017

Bench production and in vivo evaluation of vitamin loaded whey protein coacervates

Résumé

INTRODUCTION AND OBJECTIVES While functional foods have prompted growing interest to enhance the daily intakes of specific nutrients and to prevent deficiencies , their processes and storage can affect stability, solubility and bioavailability. To overcome these limitations, one alternative is the encapsulation of agents acting into carriers. To ensure industrial sustainability, such encapsulating material should be natural food-grade components (biocarriers), using economical and reliable raw materials and processes. The complex coacervation consists in mixing two polymers of opposite charges. Coacervation exploits the balance of electrostatic interactions between the two biopolymers to form a supramolecular assembly. Coacervation may display high shell integrity and encapsulation efficiency, good controlledrelease properties and mild preparation conditions. These features are interesting to reduce the industrial processing costs (Yan & Zhang, 2014). Whey proteins (WP) is by- products of the dairy industry, providing intrinsic biological properties. Two specific whey proteins has been selected β-lactoglobulin (BLG) and Lactoferrin (LF) as they able to co-assemble by complex coacervation. Recently the proof of concept that LF-BLG complex coacervates efficiently entrap vitamin B9 (B9) has been established at laboratory scale (Chapeau et al., 2016). This work focuses on the scale-up production of B9-WP coacervates for potential industrial applications. Coacervation is known to be highly sensitive to processing i.e. working volume, interfaces, and mixing conditions. Empirical scale-up could therefore result in increased costs, resources and efforts (Lemetter et al., 2004). Moreover, B9-WP coacervates should preserve the bioavailability of B9 during oral delivery. As a result, this study aims at: 1) investigating the scale-up production of B9-WP coacervate by comparing two mixing systems (in batch or in continuous), and 2) exploring the bioavailability of orally administered B9-WP coacervates.
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hal-01512156 , version 1 (21-04-2017)

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  • HAL Id : hal-01512156 , version 1
  • PRODINRA : 389663

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Anne Laure Chapeau, Pascaline Hamon, Said Bouhallab, N. Bertrand, D. Poncelet. Bench production and in vivo evaluation of vitamin loaded whey protein coacervates. 25. International Conference on Bioencapsulation, Jul 2017, La Chapelle sur Erdre, France. ⟨hal-01512156⟩
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