Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki–Miyaura cross-coupling reactions
Résumé
In positron emission tomog. [11C] PIB, Pittsburgh Compd.- B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer's disease. Synthetic routes for the prepn. of the precursor of [11C] PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple 1- step synthesis of the precursor of [11C] PIB through a Suzuki- Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2- arylbenzothiazole and 2- pyridinylbenzothiazole compds. including [18F] precursor derivs. of PIB contg. a nitro function