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Article Dans Une Revue (Article De Synthèse) ESRF Highlights Année : 2013

Structural basis for ion permeation in a pentameric ligand-gated ion channel revealed by x-ray crystallography

Marc Baaden
Marc Delarue
  • Fonction : Auteur

Résumé

Pentameric ligand-gated ion channels (pLGICs) are a major family of membrane receptors that mediate fast chemical transmission of nerve signals in the central and peripheral nervous system [1]. In vertebrates, the family encompasses the cationic selective acetylcholine and serotonine receptors, and the anionic selective glycine and γ-amino-butyric acid receptors. pLGICs are dynamic proteins that couple neurotransmitter binding in their extracellular-domain (ECD) to the opening of ion channels embedded in their transmembrane domain (TMD). The receptors share a common architecture with a large ECD and a TMD that is composed of four α-helices, named M1 to M4, that form a transmembrane pore bordered by the M2 helices (Figure 52a). The flow of ions across the membrane is inhibited by a structurally-diverse class of molecules including tricyclic antidepressants, local anaesthetics and certain transition metals that bind to the transmembrane pore. The molecular understanding of ion permeation is thus a central issue in the study of these ion channels.

Domaines

Biophysique
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Dates et versions

hal-01498088 , version 1 (29-03-2017)

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  • HAL Id : hal-01498088 , version 1

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Marc Baaden, Marc Delarue. Structural basis for ion permeation in a pentameric ligand-gated ion channel revealed by x-ray crystallography. ESRF Highlights, 2013, pp.44-45. ⟨hal-01498088⟩
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