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Article Dans Une Revue Revue des Maladies Respiratoires Année : 2017

Bench-test evaluation of spacer devices for fluticasone delivery to infants

Résumé

Introduction. - Use of a spacer device to optimize the delivery of fluticasone to infants with asthma is an important issue and clinicians require guidance around the choice of device. This in vitro study characterizes the particle size and the fluticasone delivery via 9 spacers. Methods. - We used an in vitro infant nasal cast with two different inspiratory flow rates (50 and 100 mL/s). Fluticasone particle size in the aerosol was evaluated by laser diffractometry and tracheal deposition by spectrophotometric assay. Results. - Significant differences in particle size were observed between the 9 spacers (similar D50 but D90 from 5.65 +/- 0.65 to 8.80 +/- 1.35 mu m). A 75% or higher respirable fraction was obtained for only 5 spacers. The 50 mL/s flow rate lead to the best drug delivery. At this flow, OptiChamber (R) (62 +/- 3 %) and Vortex (R) (91 +/- 8.5%) had a tracheal deposition over 50% of the initial dose of fluticasone, although the 7 other spacers exhibited a fluticasone deposition less than 25%. Discussion. - This study shows a wide variation of drug delivery between the 9 spacers studied. We demonstrate that a low inspiratory flow and a spacer showing antistatic properties facilitate drug delivery. (C) 2016 SPLF. Published by Elsevier Masson SAS. All rights reserved.
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Dates et versions

hal-01496181 , version 1 (27-03-2017)

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J. Pourchez, L. Leclerc, G. Sarry, J. -M. Vergnon, J. C. Dubus. Bench-test evaluation of spacer devices for fluticasone delivery to infants. Revue des Maladies Respiratoires, 2017, 34 (1), pp.29-35. ⟨10.1016/j.rmr.2016.02.009⟩. ⟨hal-01496181⟩
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