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Communication Dans Un Congrès Année : 2016

Abasic Sites Impact on DNA Structure and Interstrand Cross-Links Generation Modelling

Résumé

Abasic sites belong to the most common types of DNA damages. Formation of such lesions occurs spontaneously, significantly during Base Excision Repair. It has been shown that 10.000 abasic sites are generated per cell per day. These lesions are efficiently repaired by enzymes if they are isolated, but in presence of locally multiply damaged sites, repair is more difficult, nearly impossible

Domaines

Chimie
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Dates et versions

hal-01490054 , version 1 (14-03-2017)

Identifiants

  • HAL Id : hal-01490054 , version 1

Citer

Emmanuelle Bignon, Christophe Morell, Elise Dumont. Abasic Sites Impact on DNA Structure and Interstrand Cross-Links Generation Modelling. COST Action CM1201 : Biomimetic Radical Chemistry & ClicGene , Mar 2016, Grenoble, France. ⟨hal-01490054⟩
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