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Article Dans Une Revue Tetrahedron Letters Année : 2016

Biotransformations versus chemical modifications: new cytotoxic analogs of marine sesquiterpene ilimaquinone

Résumé

Highly biologically active marine sesquiterpene ilimaquinone was selected for chemical modifications. Its biotransformation was investigated using a combinatorial approach as an original way to screen different strains of microorganisms. Mucor circinelloides ATCC 8541 was able to structurally modify ilimaquinone into three different compounds. A stereospecific epoxidation was observed and compared to chemical epoxidation. A hydroxylation of the decalin ring was also observed as well as an unexpected substitution on the quinone ring by ethanolamine. Compounds were evaluated against several cell lines.
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hal-01483185 , version 1 (05-03-2017)

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Asmaa Boufridi, Sylvain Petek, Laurent Evanno, Mehdi A. Beniddir, Cécile Debitus, et al.. Biotransformations versus chemical modifications: new cytotoxic analogs of marine sesquiterpene ilimaquinone. Tetrahedron Letters, 2016, 57 (44), pp.4922-4925. ⟨10.1016/j.tetlet.2016.09.075⟩. ⟨hal-01483185⟩
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