Article Dans Une Revue Respiratory Physiology & Neurobiology Année : 2016

Carbamylated erythropoietin enhances mice ventilatory responses to changes in O2 but not CO2 levels

Résumé

Erythropoietin (EPO) has beneficial tissue-protective effects in several diseases but erythrocytosis may cause deleterious effects in EPO-treated patients. Thus carbamylated-EPO (C-EPO) and other derivatives retaining tissue-protective but lacking bone marrow-stimulating actions have been developed. Although EPO modulates ventilatory responses, the effects of C-EPO on ventilation have not been investigated. Here, basal breathing and respiratory chemoreflexes were measured by plethysmography after acute and chronic treatments with recombinant human C-EPO (rhC-EPO; 15,000 IU/kg during 5 days) or saline (control group). Hematocrit, plasma and brainstem rhC-EPO levels were also quantified. Chronic rhC-EPO significantly elevated tissue rhC-EPO levels but not hematocrit. None of the drug regimen altered basal ventilation (normoxia). Chronic but not acute rhC-EPO enhanced hyperoxic ventilatory depression, and sustained the hypoxic ventilatory response mainly via a reduction of the roll-off phase. By contrast, rhC-EPO did not blunt the ventilatory response to hypercapnia. Thus, chronic C-EPO may be a promising therapy to improve breathing during hypoxia while minimizing adverse effects on cardiovascular function.

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hal-01475546 , version 1 (23-02-2017)

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Hanan Khemiri, Marc Maresca, Christian Gestreau. Carbamylated erythropoietin enhances mice ventilatory responses to changes in O2 but not CO2 levels. Respiratory Physiology & Neurobiology, 2016, 232, pp.1 - 12. ⟨10.1016/j.resp.2016.06.002⟩. ⟨hal-01475546⟩
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