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Article Dans Une Revue Journal of Lipid Research Année : 2016

EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet

Alexandre Pinel
Sarah de Saint Vincent
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  • PersonId : 1001162
Alain Huertas
  • Fonction : Auteur
Béatrice Morio
Frédéric Capel

Résumé

Impact of ALA, EPA and DHA on obesity and metabolic complications were studied in mice fed a high-fat high-sucrose diet (HF). HF diets were supplemented with ALA, EPA or DHA (1%w/w) and given to C57BL/6J mice for 16 weeks and to Ob/Ob mice for 6 weeks. In C57BL/6J mice, EPA reduced plasma cholesterol (-20%), limited fat mass accumulation (-23%), adipose cell hypertrophy (-50%), and reduced plasma leptin concentration (-60%), compared to HF fed mice. Furthermore, mice supplemented with EPA exhibited a higher insulin sensitivity (+24%) and glucose tolerance (+20%) compared to HF fed mice. Similar effects were observed in EPA supplemented Ob/Ob mice, although fat mass accumulation was not prevented. By contrast in comparison to HF fed mice, DHA did not prevent fat mass accumulation, increased plasma leptin concentration (+128%) in C57BL/6J mice and did not improve glucose homeostasis in C57BL/6J and Ob/Ob mice. In 3T3-L1 adipocytes, DHA stimulated leptin expression whereas EPA induced adiponectin expression, suggesting that improved leptin / adiponectin balance may contribute to the protective effect of EPA. In conclusion, supplementation with EPA, but not ALA and DHA, could preserve glucose homeostasis in an obesogenic environment and limit fat mass accumulation in the early stage of weight gain.
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Dates et versions

hal-01464071 , version 1 (09-02-2017)

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Alexandre Pinel, Elodie Pitois, Jean-Paul Rigaudière, Chrystele Jouve, Sarah de Saint Vincent, et al.. EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet. Journal of Lipid Research, 2016, 57 (8), pp.1382-1397. ⟨10.1194/jlr.M065458⟩. ⟨hal-01464071⟩
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