Peptide ligation from alkoxyamine based radical addition - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2014

Peptide ligation from alkoxyamine based radical addition

Résumé

Intermolecular radical 1,2-addition (IRA) of N-tert-butyl-N-(1-diethylphosphono-2,2-dimethylpropyl)aminoxyl (SG1) based alkoxyamines onto activated olefins is used as a tool for peptide ligation. This strategy relies on simple peptide pre-derivatization to obtain (i) a SG1 nitroxide functionalized resin peptide at its N-terminus (SG1-peptide alkoxyamine), (ii) a vinyl functionalized peptide (either at its C-terminus or N-terminus), and does not require any coupling agents.

Domaines

Chimie

Dates et versions

hal-01460548 , version 1 (07-02-2017)

Identifiants

Citer

Thomas Trimaille, Laurent Autissier, Mamy Daniel Rakotonirina, Yohann Guillaneuf, Claude Villard, et al.. Peptide ligation from alkoxyamine based radical addition. Chemical Communications, 2014, 50 (21), pp.2744--2747. ⟨10.1039/c3cc49389j⟩. ⟨hal-01460548⟩
64 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More