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Article Dans Une Revue Fundamental & Clinical Pharmacology Année : 2011

Use of intravenous immunoglobulins in clinical practice: data from three French university hospitals

Elisabeth Frauger
  • Fonction : Auteur
Jerome Grassi
  • Fonction : Auteur
Vincent Pradel
Frank Rouby
Jean Delorme
  • Fonction : Auteur
Sebastien Ousset
  • Fonction : Auteur
Christine Penot-Ragon
  • Fonction : Auteur
Marie-Claude Bongrand
  • Fonction : Auteur
Jean Pouget
  • Fonction : Auteur
  • PersonId : 835082
Joëlle Micallef
Sophie Tardieu

Résumé

Since several years, the use of intravenous immunoglobulins (IVIg) has increased. This growth has encouraged some countries to publish guidelines. In parallel, some countries have conducted audits to know how IVIg are used in clinical practice in the light of the available guidelines. The objective of this study was to assess IVIg use in three French university hospitals in 2006. All IVIg administrations were evaluated during 6 months (12 September 2005-12 March 2006) in French university hospitals of Marseille. Different data were recorded for each administration: patient characteristics, indication, formulation and quantity. During the study period, 2802 administrations of IVIg (corresponding to a total quantity of 76 780 g) have been recorded. Four hundred and thirty-five patients received at least one of these administrations. The five most reported indications were multifocal motor neuropathy (11.0% of total quantity), chronic inflammatory demyelinating polyradiculoneuropathy (10.2%), corticoresistant dermatomyositis (10.2%), immune thrombocytopaenia (9.9%) and primary immune deficiency (9.1%). According to available French recommendations, 70% of the IVIg use was for 'acknowledged indications', 9% for 'indications to be assessed' and 18% for 'unwarranted indications'. The

Domaines

Chimie

Dates et versions

hal-01460290 , version 1 (07-02-2017)

Identifiants

Citer

Elisabeth Frauger, Jerome Grassi, Vincent Pradel, Charleric Bornet, Frank Rouby, et al.. Use of intravenous immunoglobulins in clinical practice: data from three French university hospitals. Fundamental & Clinical Pharmacology, 2011, 25 (6), pp.753--761. ⟨10.1111/j.1472-8206.2010.00908.x⟩. ⟨hal-01460290⟩
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