A Flexible, Stereoselective Dimethylzinc-Mediated Radical-Anionic Cascade: Dramatic Influence of Additional Lewis Acids - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2010

A Flexible, Stereoselective Dimethylzinc-Mediated Radical-Anionic Cascade: Dramatic Influence of Additional Lewis Acids

Résumé

Dimethylzinc-mediated addition of acyloxymethyl radicals to diethyl fumarate led to the highly stereoselective formation of disubstituted gamma-lactones in mean to good yields; this cascade provides a new example of a one-pot process mediated by dimethylzinc involving a tandem radical-anionic reaction; the chemoselectivity of the reaction was totally modified by additional Lewis acids.

Domaines

Chimie
Fichier non déposé

Dates et versions

hal-01460260 , version 1 (07-02-2017)

Identifiants

Citer

Julien Maury, Laurence Feray, Patricia Perfetti, Michèle P. Bertrand. A Flexible, Stereoselective Dimethylzinc-Mediated Radical-Anionic Cascade: Dramatic Influence of Additional Lewis Acids. Organic Letters, 2010, 12 (16), pp.3590--3593. ⟨10.1021/ol101519w⟩. ⟨hal-01460260⟩
36 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More