Reevaluation of possible outcomes of infections with human immunodeficiency virus - Archive ouverte HAL Access content directly
Journal Articles Clinical Microbiology and Infection Year : 2016

Reevaluation of possible outcomes of infections with human immunodeficiency virus

Abstract

Several lines of evidence indicate that HIV infection can result in several possible incomes, including a very small proportion of individuals whose HIV replication is controlled after treatment interruption (known as HIV posttreatment controllers) or spontaneously without any treatment (known as HIV elite controllers). Both types of individuals are HIV RNA negative but HIV DNA positive, with living virus which can be stimulated ex vivo. A review was conducted to assess the literature on yet rarer cases with detectable integrated HIV DNA without HIV infectious virus in HIV-seropositive or -negative individuals. Three categories of patients were identified: (a) HIV-seropositive individuals with apparent spontaneous cure from their HIV infection, (b) HIV-seronegative children born to HIV-infected mothers and (c) highly exposed seronegative adults. Validity criteria were proposed to assess the presence of integrated HIV DNA as possible or unquestionable in these three categories. Only three articles among the 22 ultimately selected fulfilled these criteria. Among the highly exposed seronegative subjects, some individuals were described as being without integrated HIV DNA, probably because these subjects were not investigated using relevant, highly sensitive methods. Finally, we propose a definition of spontaneous cure of HIV infection based on clinical, immunologic and virologic criteria. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Dates and versions

hal-01459405 , version 1 (07-02-2017)

Identifiers

Cite

C. Tamalet, Philippe Colson, Etienne Decroly, C. Dhiver, I. Ravaux, et al.. Reevaluation of possible outcomes of infections with human immunodeficiency virus. Clinical Microbiology and Infection, 2016, 22 (4), pp.299-311. ⟨10.1016/j.cmi.2015.11.022⟩. ⟨hal-01459405⟩
87 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More