VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors. - Archive ouverte HAL Access content directly
Journal Articles Trends Microbiol. Year : 2014

VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.

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Abstract

The type VI secretion system (T6SS) is a macromolecular machine that delivers protein effectors into both prokaryotic and eukaryotic cells, therefore participating in interbacterial competition and virulence. The T6SS is functionally and structurally similar to the contractile bacteriophage cell puncturing device: the contraction of a sheath-like structure is believed to propel an inner tube terminated by a spike towards target cells, allowing the delivery of effectors. In this review, we summarize recent advances in the identification and characterization of T6SS effector proteins, highlighting the broad repertoire of enzymatic activities, and discuss recent findings relating to the secretion mechanisms.
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hal-01458195 , version 1 (06-02-2017)

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Eric Durand, Christian Cambillau, E. Cascales, Laure Journet. VgrG, Tae, Tle, and beyond: the versatile arsenal of Type VI secretion effectors.. Trends Microbiol., 2014, 22 (9), pp.498--507. ⟨10.1016/j.tim.2014.06.004⟩. ⟨hal-01458195⟩
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