Betahistine Treatment Improves the Recovery of Static Symptoms in Patients With Unilateral Vestibular Loss - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Pharmacology Year : 2011

Betahistine Treatment Improves the Recovery of Static Symptoms in Patients With Unilateral Vestibular Loss

Abstract

Vestibular loss induces a combination of postural, oculomotor, and perceptive symptoms that are compensated over time. The aim of this study was to analyze the influence of betahistine dihydrochloride on vestibular compensation. A randomized, double-blind, placebo-controlled study was performed in Meniere's disease patients who underwent a curative unilateral vestibular neurotomy (UVN). The effects of betahistine treatment were investigated on a broad spectrum of vestibular-induced changes resulting from vestibular loss: body sway, head orientation, ocular cyclotorsion, spontaneous nystagmus, verticality perception, and self-evaluation of the postural stability. The time course of the recovery was compared in 16 patients who received either a placebo or betahistine (24 mg b.i.d.) from 3 days up to 3 months after UVN. Patients were examined before (day -1) and after UVN (days 7, 30, and 90). Results indicate that betahistine reduces the time to recovery by 1 month or more depending on the tested functions. Betahistine was effective as soon as 4 days after treatment administration, and the effect remained during the whole compensation period (up to 3 months). The observed clinical effects may be attributed to an action of betahistine in rebalancing the neuronal activity between contralateral vestibular nuclei.

Dates and versions

hal-01449859 , version 1 (30-01-2017)

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Christine Redon, Christophe Lopez, Laurence Bernard-Demanze, Michel Dumitrescu, Jacques Magnan, et al.. Betahistine Treatment Improves the Recovery of Static Symptoms in Patients With Unilateral Vestibular Loss. Journal of Clinical Pharmacology, 2011, 51 (4), pp.538-548. ⟨10.1177/0091270010369241⟩. ⟨hal-01449859⟩

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