Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Enzyme Inhibition and Medicinal Chemistry Année : 2005

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.

Résumé

The microwave-assisted synthesis of a family of 2,8-substituted thiazoloquinazolinones is described. The preliminary evaluation of the antiproliferative activity and the capacity of these molecules to inhibit CDKs and GSK-3 are reported. A lead compound was identified, constituting a scaffold from which more potent inhibitors could be designed.

Domaines

Biologie animale
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Dates et versions

hal-01443570 , version 1 (23-01-2017)

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Citer

Alexandra Testard, Laurent Picot, Olivier Lozach, Melina Blairvacq, Laurent Meijer, et al.. Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.. Journal of Enzyme Inhibition and Medicinal Chemistry, 2005, 20 (6), pp.557-568. ⟨10.1080/14756360500212399⟩. ⟨hal-01443570⟩
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