Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anaesthesia with propofol and sevoflurane - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences Année : 2016

Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anaesthesia with propofol and sevoflurane

Tomislav Stankovski
  • Fonction : Auteur
Johan Raeder
  • Fonction : Auteur
Andrew F. Smith
  • Fonction : Auteur
Peter V. E. Mcclintock
  • Fonction : Auteur
Aneta Stefanovska
  • Fonction : Auteur

Résumé

The precise mechanisms underlying general anaesthesia pose important and still open questions. To address them, we have studied anaesthesia induced by the widely used (intravenous) propofol and (inhalational) sevoflurane anaesthetics, computing cross-frequency coupling functions between neuronal, cardiac and respiratory oscillations in order to determine their mutual interactions. The phase domain coupling function reveals the form of the function defining the mechanism of an interaction, as well as its coupling strength. Using a method based on dynamical Bayesian inference, we have thus identified and analysed the coupling functions for six relationships. By quantitative assessment of the forms and strengths of the couplings, we have revealed how these relationships are altered by anaesthesia, also showing that some of them are differently affected by propofol and sevoflurane. These findings, together with the novel coupling function analysis, offer a new direction in the assessment of general anaesthesia and neurophysiological interactions, in general.

Domaines

Neurosciences

Dates et versions

hal-01431283 , version 1 (10-01-2017)

Identifiants

Citer

Tomislav Stankovski, Spase Petkoski, Johan Raeder, Andrew F. Smith, Peter V. E. Mcclintock, et al.. Alterations in the coupling functions between cortical and cardio-respiratory oscillations due to anaesthesia with propofol and sevoflurane. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2016, 374 (2067), ⟨10.1098/rsta.2015.0186⟩. ⟨hal-01431283⟩

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