Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate - Archive ouverte HAL
Article Dans Une Revue Tetrahedron Année : 2012

Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate

Résumé

An easily reproducible protocol allowing inter- or intramolecular spirocyclization on beta-dicarbonyl structures is described. This methodology could afford a wide variety of spirocyclic pharmacophores. As examples, highly substituted spirobenzophenanthridin-6(5H)-ones and spirolactones were synthesized. These scaffolds could be used for the design of many compounds exhibiting biological activities.

Domaines

Chimie organique
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Dates et versions

hal-01424473 , version 1 (09-01-2017)

Identifiants

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Ahlem P Bouhlel, Christophe P Curti, Michèle P Bertrand, Patrice P Vanelle. Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate. Tetrahedron, 2012, 68 (18), pp.3596-3604. ⟨10.1016/j.tet.2012.03.004⟩. ⟨hal-01424473⟩
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