Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate
Résumé
An easily reproducible protocol allowing inter- or intramolecular spirocyclization on beta-dicarbonyl structures is described. This methodology could afford a wide variety of spirocyclic pharmacophores. As examples, highly substituted spirobenzophenanthridin-6(5H)-ones and spirolactones were synthesized. These scaffolds could be used for the design of many compounds exhibiting biological activities.
Domaines
Chimie organiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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