Organic Glues or Fibrin Glues from Pooled Plasma: Efficacy, Safety and Potential as Scaffold Delivery Systems - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Pharmacy and Pharmaceutical Sciences Année : 2012

Organic Glues or Fibrin Glues from Pooled Plasma: Efficacy, Safety and Potential as Scaffold Delivery Systems

Résumé

Since 1976, fibrin glues have been attracting medical interest, spreading from their initial use as a hemostatic agent in cardiovascular surgery to other fields of surgery. Studies have compared the efficacy of fibrin glues vs sutures in surgery. However, few comparisons have been made of the efficacy and safety of the different fibrin glues commercially available. Recently, fibrin glues have been tested as a scaffold delivery system for various substances inside the body (drugs, growth factors, stem cells). The infectious risk (viruses, new germs) of this blood-derived product was also studied in assays on viral inactivation methods. The development of autologous fibrin glues offers a solution to the problem of infectious risk. This review examines the current state of knowledge on the efficacy, safety and future potential of fibrin glues.
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Dates et versions

hal-01423419 , version 1 (29-12-2016)

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Clémence Tabélé, Marc Montana, Christophe Curti, Thierry Terme, Pascal Rathelot, et al.. Organic Glues or Fibrin Glues from Pooled Plasma: Efficacy, Safety and Potential as Scaffold Delivery Systems. Journal of Pharmacy and Pharmaceutical Sciences, 2012, 15 (1), pp.124-140. ⟨10.18433/J39K5H⟩. ⟨hal-01423419⟩
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