We report a drastic enhancement of electrocatalytic activity toward glucose oxidation by using novel electrocatalysts on the basis of ``bare'' unprotected Au nanoparticles synthesized by methods of laser ablation in pure deionized water. The recorded current density of 2.65 A cm(-2) mg(-1) for glucose electrooxidation was higher than a relevant value for conventional chemically synthesized Au nanoparticles by an order of magnitude and outperformed all data reported in the literature for metal and metal alloy-based electrocatalysts. The enhanced electrocatalytic characteristics of laser-synthesized nanopartides are explained by the absence of any organic contaminants or protective ligands on their surface, the relatively small size of nanopartides, and their particular crystallographic structure. The employment of bare nanomaterials in glucose electrowddation schemes promises a radical improvement in current biofuel cell bioimplantable devices.