Static and dynamic in vitro digestion models to study proteins stability in the gastrointestinal tract
Résumé
Food protein allergenicity has been linked to the survival of the allergen in the gastrointestinal tract. Therefore,
in vitro digestion models have been widely used as tools to help predicting allergenicity. A huge diversity
of static in vitro digestion models based on different experimental conditions have been proposed in the
literature making the comparison between studies impossible. For this reason, an internationally harmo-
nized static model has recently been developed. Dynamic in vitro digestion models are complex but more
physiologically relevant and could represent an excel-lent alternative to study allergenic food digestion.
Overall, these models have shown that the ability of a protein to survive in the gastrointestinal tract highly
depends on whether the protein is pure or embedded into a complex food matrix.