Reducing Invalid Connections with Microstructure-Driven Tractography
Résumé
Diffusion-weighted imaging (DWI) tractography has become the tool of choice to probe the
human brain's white matter (WM) in vivo. However, tractography algorithms produce a large number
erroneous/invalid streamlines [1] largely due to complex ambiguous local fiber configurations (e.g. crossing,
kissing or fanning). Moreover, the relationship between the resulting streamlines and the underlying WM
microstructure characteristics, such as axon diameter, remains poorly understood [2]. The distinctive aspect of our
tractography algorithm from previous methods is the active use of microstructure information about fascicles during
the tracking. This enables us to solve areas of complex tissue configuration and separate parallel fascicles with
different microstructure characteristics, hence improving the overall tractography process.
Domaines
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