The self-configuration process can simplify the complexity and reduce the cost of the management and deployment of devices, applications and services in smart spaces. Mechanisms inspired from the Autonomic Computing and Pervasive Computing can be used to automate management of the heterogeneous space's component. In this paper, we present our work on Autonomic Pervasive Computing and mainly the self-configuration process. We also introduce our self-configuration middleware that is deployed at DOMUS Laboratory