We report the thermodynamic potential for single-domain (110) thin films epitaxially grown on dissimilar cubic substrates. Using different sets of paraelectric phase elastic compliance coefficients of PbTiO 3 single crystal, calculated from the experimental room-temperature values, we predict rotational phases similar to those observed in (001) thin films under anisotropic biaxial misfit strain. The new sets of elastic compliance coefficients also predict a triclinic phase that could potentially lead to the enhancement of both dielectric and piezoelectric properties. We also conducted experimental studies on highly tetragonal monocrystalline PbZr 0.05 Ti 0.95 O 3 thin films of different thicknesses, epitaxially grown on (110) SrTiO 3 substrate by pulsed laser deposition technique. Piezoresponse force microscopy measurements showed that the as-grown films were single domain with the a 2 c phase, which corroborates with the prediction of the theory. Moreover, the T c values of both thin and thick films (17–90 nm) also fell within the predicted range (540–600 ± • C). The measured remanet polarization of 57 µC/cm 2 was in good agreement with the theoretical values of 55–58 µC/cm 2. Small-signal piezoelectric response measurements gave a piezoelectric coefficient of 40 pm/V, which is also in good agreement with the numerically calculated values of 38–42 pm/V.