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Article Dans Une Revue Brain imaging and behavior (Brain Imaging Behav) Année : 2017

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Tulio Guadalupe (1, 2) , Samuel R. Mathias (3) , Theo G. M. Vanerp (4) , Christopher D. Whelan (5) , Marcel P. Zwiers (6) , Yoshinari Abe (7) , Lucija Abramovic (8) , Ingrid Agartz (9) , Ole A. Andreassen (10) , Alejandro Arias-Vásquez (11, 12) , Benjamin S. Aribisala (13, 14) , Nicola J. Armstrong (15) , Volker Arolt (16) , Eric Artiges (17) , Rosa Ayesa-Arriola (18, 19) , Vatche G. Baboyan (20) , Tobias Banaschewski (21) , Gareth Barker (22) , Mark E. Bastin (13) , Bernhard T. Baune (23) , John Blangero (24, 25) , Arun L.W. Bokde (26) , Premika S.W. Boedhoe (27) , Anushree Bose (28) , Silvia Brem (29) , Henry Brodaty (30, 31) , Uli Bromberg (32) , Samantha Brooks , Christian Büchel (32) , Jan Buitelaar (33) , Vince D. Calhoun (34, 35) , Dara M. Cannon (36) , Anna Cattrell (37) , Yuqi Cheng (38) , Patricia J. Conrod (37) , Anne Conzelmann (39) , Aiden Corvin (40, 41) , Benedicto Crespo-Facorro (19) , Fabrice Crivello (42) , Udo Dannlowski (43) , Greig I. de Zubicaray (44) , Sonja M.C. de Zwarte (8) , Ian J. Deary , Sylvane Desrivières (37) , Nhat Trung Doan , Gary Donohoe (36, 41) , Erlend S. Dørum (10) , Stefan Ehrlich (45) , Thomas Espeseth (46, 10) , Guillén Fernández (47) , Herta Flor (48) , Paul Fouche (47) , Vincent Frouin (49) , Masaki Fukunaga (50) , Jürgen Gallinat (51) , Hugh Hu (47) , Michael Gill (52) , Andrea Gonzalez Suarez (47) , Penny Gowland (53) , Hans J. Grabe (54) , Dominik Grotegerd (43) , Oliver Gruber (47) , Saskia Hagenaars (47) , Ryota Hashimoto (55) , Tobias U. Hauser (56) , Andreas Heinz (47) , Derrek P. Hibar (5) , Pieter J. Hoekstra (57) , Martine Hoogman (6) , Fleur M. Howells (47) , Hao Hu (47) , Hilleke E. Hulshoff Pol (8) , Chaim Huyser (47) , Bernd Ittermann (51) , Neda Jahanshad (5) , Erik G. Jönsson (58) , Sarah Jurk (47) , Rene S. Kahn (59) , Sinead Kelly (60) , Bernd Kraemer (61) , Harald Kugel (43) , Jun Soo Kwon (62) , Herve Lemaitre (63) , Klaus-Peter Lesch (64) , Christine Lochner (47) , Michelle Luciano (65) , Andre F. Marquand (66) , Nicholas G. Martin , Ignacio Martínez-Zalacaín (47) , Jean-Luc Martinot (67, 68) , David Mataix-Cols (47) , Karen Mather (69) , Colm Mcdonald (70) , Katie L. Mcmahon (71) , Sarah E. Medland (72) , José M. Menchón (73, 74) , Derek W. Morris (75) , Omar Mothersill (47) , Susana Munoz Maniega (47) , Benson Mwangi (47) , Takashi Nakamae (47) , Tomohiro Nakao (47) , Janardhanan C. Narayanaswaamy (47) , Frauke Nees (21) , Jan E. Nordvik (76, 77) , A. Marten H. Onnink (47) , Nils Opel (47) , Roel Ophoff (78) , Marie-Laure Paillère Martinot (67) , Dimitri Papadopoulos-Orfanos (49) , Paul Pauli (47) , Tomáš Paus (79) , Luise Poustka (48) , Janardhan Yc. Reddy (80) , Miguel E. Renteria (81) , Robert Roiz-Santiáñez (19) , Annerine Roos (82) , Natalie A. Royle (13) , Perminder Sachdev (83) , Pascual Sánchez-Juan (84) , Lianne Schmaal (85) , Gunter Schumann (86) , Elena Shumskaya (47) , Michael N. Smolka (87) , Jair C. Soares (88) , Carles Soriano-Mas (89) , Dan J. Stein (90) , Lachlan T. Strike (91, 92, 72) , Roberto Toro (93) , Jessica A. Turner (94) , Nathalie Tzourio-Mazoyer (42) , Anne Uhlmann (47) , Maria Valdés Hernández (95) , Odile A. van den Heuvel (96) , Dennis van Der Meer (97) , Neeltje E.M . van Haren (8) , Dick J. Veltman (85) , Ganesan Venkatasubramanian (47) , Nora C. Vetter (47) , Daniella Vuletic (47) , Susanne Walitza (16) , Henrik Walter (51, 98) , Esther Walton (99) , Zhen Wang (100) , Joanna Wardlaw (13) , Wei Wen (101) , Lars T. Westlye (46, 10) , Robert Whelan (102) , Katharina Wittfeld (103, 104) , Thomas Wolfers (47) , Margaret J. Wright (105) , Jian Xu (106) , Xiufeng Xu (47) , Je-Yeon Yun (107) , Jingjing Zhao (47) , Barbara Franke (33) , Paul M. Thompson (20) , David C. Glahn (108) , Bernard Mazoyer (42) , Simon E. Fisher (33) , Clyde Francks (2, 6, 93)
1 IMPRS - International Max Planck Research School for Language Sciences
2 Language and Genetics Department [Nijmegen]
3 Yale University [New Haven]
4 Department of Psychiatry and Human Behavior
5 David Geffen School of Medicine [Los Angeles]
6 Donders Institute for Brain, Cognition and Behaviour
7 Department of Psychiatry, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan
8 University Medical Center [Utrecht]
9 KG Jebsen Centre for Psychosis Research
10 UiO - University of Oslo
11 Department of Human Genetics
12 Department of Psychiatry
13 Edin. - University of Edinburgh
14 LASU - Lagos State University
15 HWU - Heriot-Watt University [Edinburgh]
16 Mental Health Sciences Unit
17 Adolescent psychopathology and Medicine
18 CIBERSAM - Centro de Investigación Biomédica en Red de Salud Mental
19 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
20 USC - University of Southern California
21 Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim]
22 Centre for Neuroimaging Sciences, Institute of Psychiatry
23 Department of Psychiatry
24 UTHealth - The University of Texas Health Science Center at Houston
25 Texas Biomedical Research Institute [San Antonio, TX]
26 Discipline of Psychiatry [Dublin]
27 VU University Medical Center [Amsterdam]
28 National Institute of Mental Health and Neurosciences [Bagalore, India]
29 Hospital of the University of Pennsylvania, Department of Neurosurgery
30 Dementia Collaborative Research Centre
31 Centre for Healthy Brain Ageing
32 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
33 Donders Center for Cognitive Neuroimaging
34 The Mind Research Network
35 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]
36 Human Genetics Branch
37 Institute of Psychiatry, Psychology & Neuroscience, King's College London
38 Chinese CDC - Center for disease control, China
39 Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Germany, Tübingen, Würzburg, Germany
40 Neuropsychiatric Genetics Research Group
41 Department of Psychiatry
42 GIN - [GIN] Grenoble Institut des Neurosciences
43 Department of Psychiatry
44 School of Psychology, University of Queensland
45 MetaGenoPolis
46 Department of Psychology [Oslo]
47 Sans affiliation
48 Universität Mannheim
49 NEUROSPIN - Service NEUROSPIN
50 Division of Cerebral Integration National Institute for Physiological Sciences Okazaki Japan
51 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
52 University of Calgary
53 Sir Peter Mansfield Magnetic Resonance Centre [Nottingham]
54 Department of Psychiatry and Psychotherapy
55 Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development,
56 UCCAP - University Clinic for Child and Adolescent Psychiatry
57 Department of Psychiatry
58 Department of Medicine, Clinical Pharmacology Unit
59 Brain Centre Rudolf Magnus [Utrecht]
60 MetaCase [Jyväskylä]
61 Georg-August-University = Georg-August-Universität Göttingen
62 SNU - Seoul National University [Seoul]
63 UCP - Université de Cergy Pontoise
64 Institute of Human Genetics
65 Medstar Research Institute
66 Donders Centre for Cognitive Neuroimaging
67 U1000 - Neuroimagerie en psychiatrie
68 IFR 49 - IFR de Neuroimagerie Fonctionnelle
69 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
70 Department of Life Sciences
71 Centre for Advanced Imaging
72 Queensland Institute of Medical Research
73 IDIBELL - Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
74 UB - Universitat de Barcelona
75 NUI Galway - National University of Ireland [Galway]
76 Climate Change Unit [Ispra]
77 Sunnaas Rehabilitation Hospital HT Nesodden Norway
78 Department of Psychiatry
79 MNI - McConnell Brain Imaging Centre
80 Texas A&M University [College Station]
81 QIMR Berghofer Medical Research Institute
82 UvA - Universiteit van Amsterdam
83 Centre for Healthy Brain Ageing [Sydney]
84 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas
85 Department of Psychiatry
86 Göttingen Zentrum Geowissenschaften
87 TU Dresden - Technische Universität Dresden = Dresden University of Technology
88 Instituto de Geociências, Universidade de Brasília
89 Magnetic Resonance Imaging
90 Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
91 Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia
92 School of Psychology, University of Queensland, Brisbane 4072, Australia
93 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
94 University of York [York, UK]
95 Centre for Cognitive Ageing & Cognitive Epidemiology
96 Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
97 University of Twente
98 Berlin School of Mind and Brain [Berlin]
99 EDC - Centre épigénétique et destin cellulaire
100 Department of Computational and Applied Mathematics [Houston]
101 Department of Physics [Hong Kong University of Science and Technology]
102 UCD - University College Dublin [Dublin]
103 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
104 Greifswald University Hospital
105 Mizzou - University of Missouri [Columbia]
106 MSMP - Mechanics surfaces and materials processing
107 Department of Genetics
108 Dpt of Psychiatry [New Haven]
Samantha Brooks
  • Fonction : Auteur
Fabrice Crivello
Ian J. Deary
  • Fonction : Auteur
Nhat Trung Doan
  • Fonction : Auteur
Stefan Ehrlich
  • Fonction : Auteur
Herta Flor
  • Fonction : Auteur
Paul Fouche
  • Fonction : Auteur
Vincent Frouin
Hugh Hu
  • Fonction : Auteur
Oliver Gruber
  • Fonction : Auteur
Andreas Heinz
  • Fonction : Auteur
Hao Hu
  • Fonction : Auteur
Chaim Huyser
  • Fonction : Auteur
Sarah Jurk
  • Fonction : Auteur
Nicholas G. Martin
  • Fonction : Auteur
Omar Mothersill
  • Fonction : Auteur
Benson Mwangi
  • Fonction : Auteur
Takashi Nakamae
  • Fonction : Auteur
Tomohiro Nakao
  • Fonction : Auteur
Nils Opel
  • Fonction : Auteur
Paul Pauli
  • Fonction : Auteur
Perminder Sachdev
Elena Shumskaya
  • Fonction : Auteur
Anne Uhlmann
  • Fonction : Auteur
Dennis van Der Meer
Nora C. Vetter
  • Fonction : Auteur
Thomas Wolfers
  • Fonction : Auteur
Jian Xu
Xiufeng Xu
  • Fonction : Auteur
Jingjing Zhao
Bernard Mazoyer

Résumé

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

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Neurosciences
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hal-01382787 , version 1 (20-10-2016)

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Tulio Guadalupe, Samuel R. Mathias, Theo G. M. Vanerp, Christopher D. Whelan, Marcel P. Zwiers, et al.. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain imaging and behavior (Brain Imaging Behav), 2017, 11 (5), pp.1497-1514. ⟨10.1007/s11682-016-9629-z⟩. ⟨hal-01382787⟩
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