In this paper, we present an improved Mesh of Clusters (MoC) architecture with new hierarchical Switch Box (SB) topology and depopulated intra-cluster interconnect with flexible Rent’s parameter. The aim of this paper is to explore the effect of different architecture parameters like architecture Rent’s, design Rent’s and channel width. Then, we analyze how these factors interact and the way to tune them to satisfy various specific application constraints and quality metrics like power consumption and area. The proposed exploration methodology unifies two procedures which are analytical method based on Rent’s rule modeling and experimental method based on benchmarks circuits implementation. A comparison with VPR mesh architecture shows gains in terms power and area equal respectively to 30% and 32%.