Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Inorganic Biochemistry Année : 2016

Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity.

Résumé

The synthesis and characterization of the complexes [PdX(PPh3)(4-MeT)]X (4-MeT = 4-methyl-3-thiosemicarbazide; PPh3 = triphenylphosphine; X = Cl, Br, I, SCN) have been described. The complexes were evaluated for in vitro activity as cytotoxic agents on tumor cells and also as cathepsin B and topoisomerase I and II inhibitors.

Domaines

Chimie

Dates et versions

hal-01367474 , version 1 (16-09-2016)

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Citer

Fillipe V. Rocha, Carolina V. Barra, Saulo S. Garrido, Francine A. Manente, Iracilda Z. Carlos, et al.. Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity. . Journal of Inorganic Biochemistry, 2016, 159, pp.165-168. ⟨10.1016/j.jinorgbio.2016.02.039⟩. ⟨hal-01367474⟩
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