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Article Dans Une Revue RSC Advances Année : 2015

Functionalizable red emitting calcium sensor bearing a 1,4-triazole chelating moiety

Mayeul Collot
Christian Wilms
  • Fonction : Auteur

Résumé

Herein we developed a functionalizable OFF-ON red emitting fluorescent calcium probe based on a new chelating system formed by CuAAC click chemistry (Huisgen cycloaddition). The pro-sensor 7 which is not sensitive to Ca2+, contains an alkyne moiety that, upon the click reaction, forms a chelating group involving the 1,4-triazole. Probe 10 exhibited good sensitivity towards calcium (K-d = 5.8 mu M) and zinc (5.6 mu M) with a high dynamic range (65 fold fluorescence increase), high quantum yield (0.59) and showed very low fluorescence enhancement in the presence of a high concentration of Mg2+. We extended this method and generated two dextran conjugates in order to compare their sensing properties with those of the molecular form of 10.
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Dates et versions

hal-01362703 , version 1 (09-09-2016)

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Mayeul Collot, Christian Wilms, Jean-Maurice Mallet. Functionalizable red emitting calcium sensor bearing a 1,4-triazole chelating moiety. RSC Advances, 2015, 5 (9), pp.6993-7000. ⟨10.1039/c4ra12858c⟩. ⟨hal-01362703⟩
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