Optimal control of multiple magnetic microbeads navigating in microfluidic channels
Résumé
This paper presents an optimal control strategy for navigation of multiple magnetic microbeads for future drug targeting applications. To transport the drugs, we use therapeutic magnetic microbeads as navigable agents controlled by magnetic gradients. The main difficulty is to control independently each therapeutic agent along a trajectory with the same magnetic gradient fields. This study proposes an optimal control methodology to control a group of different therapeutic agents at desired states. Based on a dynamic model of group of magnetic microbeads, controllability and observability conditions are formulated and simulated. Based on the proposed theoretical analysis a linear quadratic with integral action control (LQI) has been chosen to be applied to the microbeads system. Finally, an experimental investigation is carried out in millimeter-sized fluidic artery vessels to demonstrate the controllability and stability of two magnetic microbeads under different velocity and trajectory constraints with a laminar viscous fluidic environment.
Mots clés
Magnetic separation
Magnetic resonance imaging
observability
optimal control
LQI
controllability conditions
drug targeting applications
laminar viscous fluidic environment
linear quadratic with integral action control
magnetic gradient fields
microfluidic channels
millimeter-sized fluidic artery vessels
multiple magnetic microbeads
observability conditions
therapeutic magnetic microbeads
trajectory constraints
velocity constraints
Controllability
Magnetic moments
microchannel flow
linear quadratic control
laminar flow
flow control
drug delivery systems
Magnetic tunneling
Micromagnetics
Saturation magnetization
Origine : Fichiers produits par l'(les) auteur(s)
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