The last decade has seen an impressive development of the research dedicated to the biomedical applications of Low Temperature Non Thermal Plasmas (LTNTP), ionized gases at temperature close to the ambient one. This is especially true with plasma sources working at atmospheric pressure allowing direct applications on human. Medical applications of LTNTP now concern a very wide range of domains from wound healing [1] to cancer treatment [2,3] or transdermal drug delivery [4] . These applications also include dermatology closely linked to cosmetic. At atmospheric pressure, LTNTP are mainly produced by Dielectric Barrier Discharges (DBD) or by single/multi plasma jets, both types based on electrical discharges at very low power. The produced plasmas emit light in wide wavelength range and contain charged species and reactive species which concentrations depend on discharge configuration and electrical parameters. In addition, LTNTP produce external electric field which can, not only, be applied locally in combination with the species mentioned above, but also alone. All of their characteristics render them very attractive for potential applications in cosmetic especially anti-aging through skin structure modifications, hydration, and oxygenation or skin care product delivery. In this presentation, after a very brief reminder on the plasma state, we will first present the different ways to produce atmospheric LTNTP and discuss about their properties (including those related to transient electric field), in particular the ones of clear interest for cosmetic. Then we will give a brief review on the ongoing biomedical plasma research and applications, with a special focus on the ones related to dermatology treatments. We will end by a survey of possible developments and use in cosmetic.AcknowledgmentsThis work is supported by the ARD2020 COSMETSCIENCES Project “PLASMACOSM”References[1] J Heinlin, G Isbary, et a,l JEADV (2011) 25, 1–11[2] H.R. Metelmann et al Clin. Plas Med. doi.org/10.1016/j.cpme.2015.02.001[3] L. Brullé et al, PLOS ONE, 7, DOI: 10.1371/journal.pone.0052653 (2012)[4] S. Khalgathi, ISPC 22nd proceedings, O-22-6 (2015)