Surface Functionalization of the Metal Oxide Nanoparticles with Biologically Active Molecules Containing Phosphonate Moieties. Case Study of BaTiO 3
Résumé
Recent development in the field of nanoscience and nanotech-nology has set strong focus on synthetic approaches to complex assemblies of nanoparticles with the prospects of application in optics, electromagnetism, as well as in bioimaging and pharmaceutics. 1,2 Metal oxide nanoparticles are broadly recognized as attractive materials for the creation of such systems. 3,4 The most commonly applied approach to stabilization of dispersions of metal oxide nanoparticles is based on grafting of organic polymer molecules on their surface. The applied polymer stabilizers involved dextranes, 5 chitosans, 6,7 and carboxylate sur-factants together with block-copolymers, 8 poly-N,N-dimethy-lakrylamide, 9 linear polysaccharides, 10 and so forth. Their use normally leads to formation of self-assembled monolayers (SAMs) effectively shielding the modified oxide particle. 11À13