Evaluation of the capability of the PCV2 genome to encode miRNAs: lack of viral miRNA expression in an experimental infection - Archive ouverte HAL Access content directly
Journal Articles Veterinary Research Year : 2015

Evaluation of the capability of the PCV2 genome to encode miRNAs: lack of viral miRNA expression in an experimental infection

Fernando Núñez-Hernández
  • Function : Author
  • PersonId : 979794
Lester J Pérez
  • Function : Author
  • PersonId : 981654
Gonzalo Vera
  • Function : Author
  • PersonId : 979797
Sarai Córdoba
  • Function : Author
  • PersonId : 979800
Joaquim Segalés
  • Function : Author
  • PersonId : 979595
Armand Sánchez
  • Function : Author
  • PersonId : 979801
José I Núñez
  • Function : Correspondent author
  • PersonId : 981655

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Abstract

AbstractPorcine circovirus type 2 (PCV2) is a ssDNA virus causing PCV2-systemic disease (PCV2-SD), one of the most important diseases in swine. MicroRNAs (miRNAs) are a new class of small non-coding RNAs that regulate gene expression post-transcriptionally. Viral miRNAs have recently been described and the number of viral miRNAs has been increasing in the past few years. In this study, small RNA libraries were constructed from two tissues of subclinically PCV2 infected pigs to explore if PCV2 can encode viral miRNAs. The deep sequencing data revealed that PCV2 does not express miRNAs in an in vivo subclinical infection.
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Dates and versions

hal-01309782 , version 1 (30-04-2016)

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Fernando Núñez-Hernández, Lester J Pérez, Gonzalo Vera, Sarai Córdoba, Joaquim Segalés, et al.. Evaluation of the capability of the PCV2 genome to encode miRNAs: lack of viral miRNA expression in an experimental infection. Veterinary Research, 2015, 46 (1), pp.48. ⟨10.1186/s13567-015-0181-4⟩. ⟨hal-01309782⟩

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