The number of patients with complications associated with chronic diseases increases with the aging population. In particular, complex chronic wounds raise the re-admission rate in hospitals. In this context, the implementation of a telemedicine application in Basse Normandie, France, contributes to reduce hospital stays and transport. This application requires a new collaboration among general practitioners, private duty nurses and the hospital staff. However, the main constraint mentioned by the users of this system is the lack of interoperability between the information system of this application and various partners’ information systems. In order to improve medical data exchanges, we propose a new implementation based on the introduction of interoperable clinical documents and a digital document repository for managing the sharing of the documents between the telemedicine application users. We then show that this technical solution is suitable for any telemedicine application and any document sharing system in a healthcare facility or network.