Characterisation of tissue microstructure on excised dog livers using the structure factor model - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2015

Characterisation of tissue microstructure on excised dog livers using the structure factor model

Résumé

Quantitative ultrasound (QUS) techniques utilize the amplitude and frequency dependence of the backscatter coefficient (BSC) to determine the physical properties of the average tissue microstructure. QUS techniques typically rely on theoretical scattering models to fit the BSC from biological tissues to an estimated BSC using an appropriate theoretical model. The Structure Factor Model (SFM) was recently shown to better explain the BSCs from tissue-mimicking biophantoms (Franceschini et al JASA 2014). The aim of this study is to use the SFM to estimate the tissue microstructure in excised canine livers. Ultrasonic backscatter measurements were performed in excised canine livers at frequencies ranging from 12 MHz to 38 MHz using an ultrasound scanner (Vevo 770, Visualsonics, Toronto, Canada) equipped with the RMV 707 probe. The mean scatterer radius r*, scatterer concentration ϕ* and impedance contrast Gz* were estimated using the SFM. The estimated parameters were classified according to the concentration estimates as a diluted medium (ϕ*<0.08) or a concentrated medium (ϕ*≥0.08). The structural parameters classified as diluted medium (ϕ*<0.08) were equal to r*=5.43±0.95 µm, ϕ*=0.022±0.013 and Gz*=0.12±0.04 for most estimates (77%). The estimated scatterer radius closely corresponded to the actual radius of the hepatocyte nuclei. By assuming that the hepatocyte cells occupy a volume fraction around 0.74 and that 15% of the cells are bi-nucleated, the nuclear volume fraction is expected to equal approximately 0.039. A good match was thus obtained between the estimated and expected nuclear volume fractions using the SFM.
Fichier non déposé

Dates et versions

hal-01297423 , version 1 (04-04-2016)

Identifiants

  • HAL Id : hal-01297423 , version 1

Citer

Emilie Franceschini, Jiangang Chen, Garry Hou, Fabrice Marquet, Elisa Konofagou. Characterisation of tissue microstructure on excised dog livers using the structure factor model. International Congress on Ultrasonics, May 2015, Metz, France. ⟨hal-01297423⟩
58 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More