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Communication Dans Un Congrès Année : 2015

Structure-factor model for quantifying the ultrasound scattering from concentrated cell pellet biophantoms

Résumé

Ultrasonic backscatter coefficient (BSC) measurements were performed on K562 cell pellet biophantoms with cell concentrations ranging from 0.6% to 30% using ultrasound in the 10-42MHz frequency band. The concentrated biophantoms mimic densely packed cells with known concentrations and are thus simplified versions of real tumor. Three scattering models, the fluid-filled-sphere model (FFSM), the Gaussian model (GM), and the structure factor model (SFM), were compared for modeling the scattering of the biophantoms. The GM and FFSM assume sparse, independently, and randomly distributed scatterers and are thus suitable for modelling dilute media; however, the SFM does not contain these assumptions and therefore can model dense media accurately. First, a parameter-estimation procedure was developed to estimate scatterer size and acoustic impedance contrast (assuming that cell concentrations were known a priori) and thereby compare theoretical with measured BSCs for all studied concentrations. The SFM yielded scatterer-radius estimates of 6.4 μm, which were consistent with the cell radius measured by optical microscopy. Second, the ability of the three models to estimate the scatterer size and acoustic concentration was compared. These scatterer properties were predicted well by the SFM, whereas the GM and the FFSM underestimated cell size and overestimated acoustic concentration for the more-concentrated biophantoms.
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Dates et versions

hal-01297402 , version 1 (04-04-2016)

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Emilie Franceschini, Romain de Monchy, Jonathan Mamou. Structure-factor model for quantifying the ultrasound scattering from concentrated cell pellet biophantoms. Acoustical Society of America meeting, Nov 2015, Jacksonville, United States. pp.1797, ⟨10.1121/1.4933700⟩. ⟨hal-01297402⟩
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