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Article Dans Une Revue New Journal of Chemistry Année : 2016

Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

Résumé

A porphyrin monosubstituted by three triethyleneglycol chains grafted on a pentaerythritol skeleton was designed to display an optimized amphiphilicity for an enhanced cellular uptake and thus to exert enhanced photocytotoxicity. This porphyrin proved to be an excellent photosensitiser with submicromolar IC50.
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Dates et versions

hal-01288201 , version 1 (14-03-2016)

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Derya Topkaya, Dominique Lafont, Florent Poyer, Guillaume Garcia, Florian Albrieux, et al.. Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity. New Journal of Chemistry, 2016, 40 (3), pp.2044-2050. ⟨10.1039/C5NJ02716K⟩. ⟨hal-01288201⟩
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