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Article Dans Une Revue Angewandte Chemie International Edition Année : 2016

Mass Determination of Entire Amyloid Fibrils by Using Mass Spectrometry

Résumé

Amyloid fibrils are self-assembled protein structures with important roles in biology (either pathogenic or physiological), and are attracting increasing interest in nanotechnology. However, because of their high aspect ratio and the presence of some polymorphism, that is, the possibility to adopt various structures, their characterization is challenging and basic information such as their mass is unknown. Here we show that charge-detection mass spectrometry, recently developed for large self-assembled systems such as viruses, provides such information in a straightforward manner.

Domaines

Chimie

Dates et versions

hal-01284122 , version 1 (07-03-2016)

Identifiants

Citer

Tristan Doussineau, Carole Mathevon, Lucie Altamura, Charlotte Vendrely, Philippe Dugourd, et al.. Mass Determination of Entire Amyloid Fibrils by Using Mass Spectrometry. Angewandte Chemie International Edition, 2016, 55 (7), pp.2340-2344. ⟨10.1002/anie.201508995⟩. ⟨hal-01284122⟩
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