In this paper, a Multi Layer Perceptron (MLP) based Artificial Immune System (AIS) is presented for breast cancer classification. The proposed algorithm integrates clonal selection principle of AIS in MLP learning to reduce its computational costs and accelerate its convergence to a Mean Squared Error Threshold (MSEth) set by the user. Applied on the Wisconsin Diagnosis Breast Cancer database (WDBC), the results show that combining Artificial Immune Systems and Neural Networks is effective. Indeed, a significant reduction of computation time has been obtained with a slight improvement of classification accuracy.