Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Allergy Année : 2016

Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms.

Angèle Soria

Résumé

The main metabolism pathway of tryptophan is protein formation, but it can also be metabolized into serotonin and kynurenine. Indoleamine 2,3-dioxygenase (IDO) is the enzyme that catalyzes the degradation of tryptophan into kynurenine. Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in various tissues with 57% of patients having gastrointestinal involvement. We studied tryptophan metabolism in mastocytosis patients displaying or not gastrointestinal features and healthy subjects (n = 26 in each group). Mastocytosis patients with digestive symptoms displayed significantly increased kynurenine level and IDO activity as compared to healthy controls and mastocytosis patients without digestive symptoms. This could be linked to mast cell-mediated digestive inflammation among patients with mastocytosis. This work is the first focusing on kynurenine pathway in a mast cell disease and could help to understand the pathogenesis of digestive features in mastocytosis as well as in other mast cell-mediated diseases.
Fichier principal
Vignette du fichier
Georgin-Lavialle_2016_Decreased.pdf (281.85 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01269697 , version 1 (23-03-2016)

Identifiants

Citer

Sophie Georgin-Lavialle, Jean-Marie Launay, Francine Côté, Erinn Soucié, Angèle Soria, et al.. Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms.. Allergy, 2016, 71 (3), pp.416-420. ⟨10.1111/all.12802⟩. ⟨hal-01269697⟩
832 Consultations
1662 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More