Host-virus shift of the sphingolipid pathway along an Emiliania huxleyi bloom: survival of the fattest - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Environmental Microbiology Année : 2009

Host-virus shift of the sphingolipid pathway along an Emiliania huxleyi bloom: survival of the fattest

Antonio Pagarete
  • Fonction : Auteur
Michael J. Allen
  • Fonction : Auteur
William H. Wilson
  • Fonction : Auteur
Susan A. Kimmance
  • Fonction : Auteur

Résumé

The interactions between viruses and phytoplankton play a key role in shaping the ecological and evolutionary dynamics of oceanic ecosystems. One of the most fascinating examples of horizontal gene transfer between a eukaryotic host and its virus is a de novo sphingolipid biosynthesis pathway (SBP) found in the genomes of both Emiliania huxleyi and its coccolithovirus EhV-86. Here, we focus on a natural E. huxleyi/coccolithovirus system off the coast of Norway and investigate the dynamics of host and virus homologous gene expression for two of the most important sphingolipid biosynthesis enzymes, serine palmitoyl transferase (SPT) and dihydroceramide desaturase (DCD). Transcriptional dynamics display three defined stages along E. huxleyi bloom formation and decline, with the coccolithovirus transcripts taking over and controlling the SBP in stages 2 and 3. The observed patterns fit the hypothesis according to which viral sphingolipids are involved in the timing and physical processes of virion release from the host cells. This study provides a unique insight into the transcriptional interplay of homologous metabolic pathways between virus and host during temporal progression of oceanic E. huxleyi blooms.

Dates et versions

hal-01258269 , version 1 (18-01-2016)

Identifiants

Citer

Antonio Pagarete, Michael J. Allen, William H. Wilson, Susan A. Kimmance, Colomban de Vargas. Host-virus shift of the sphingolipid pathway along an Emiliania huxleyi bloom: survival of the fattest. Environmental Microbiology, 2009, 11 (11), pp.2840-2848. ⟨10.1111/j.1462-2920.2009.02006.x⟩. ⟨hal-01258269⟩
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