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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2014

Fluorescent push–pull pH-responsive probes for ratiometric detection of intracellular pH

Résumé

A family of fluorescent push-pull pH-responsive probes based on 2-dicyanomethylidene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran as a strong electron acceptor group is described. Small structural variations allow obtaining pK(a) ranging from 4.8 to 8.6, underlining the role of the substituent in modulating the acidic properties. Remarkable changes in the optical properties (in particular the fluorescence intensity ratios) were observed as a function of pH. The most interesting probes with pK(a) close to neutrality were used for ratiometric imaging of intracellular pH.
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Dates et versions

hal-01245464 , version 1 (17-12-2015)

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Martin Ipuy, Cyrielle Billon, Guillaume Micouin, Jacques Samarut, Chantal Andraud, et al.. Fluorescent push–pull pH-responsive probes for ratiometric detection of intracellular pH. Organic & Biomolecular Chemistry, 2014, 12 (22), pp.3641-3648. ⟨10.1039/c4ob00147h⟩. ⟨hal-01245464⟩
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