Selective antibacterial effects of mixed ZnMgO nanoparticles - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Nanoparticle Research Année : 2013

Selective antibacterial effects of mixed ZnMgO nanoparticles

Résumé

Antibiotic resistance has impelled the research for new agents that can inhibit bacterial growth without showing cytotoxic effects on humans and other species. We describe the synthesis and physicochemical characterization of nanostructured ZnMgO whose antibacterial activity was compared to its pure nano-ZnO and nano-MgO counterparts. Among the three oxides, ZnO nanocrystals-with the length of tetrapod legs about 100 nm and the diameter about 10 nm-were found to be the most effective antibacterial agents since both Gram-positive (B. subtilis) and Gram-negative (E. coli) bacteria were completely eradicated at concentration of 1 mg/mL. MgO nanocubes (the mean cube size similar to 50 nm) only partially inhibited bacterial growth, whereas ZnMgO nanoparticles (sizes corresponding to pure particles) revealed high specific antibacterial activity to Gram-positive bacteria at this concentration. Transmission electron microscopy analysis showed that B. subtilis cells were damaged after contact with nano-ZnMgO, causing cell contents to leak out. Our preliminary toxicological study pointed out that nano-ZnO is toxic when applied to human HeLa cells, while nano-MgO and the mixed oxide did not induce any cell damage. Overall, our results suggested that nanostructured ZnMgO, may reconcile efficient antibacterial efficiency while being a safe new therapeutic for bacterial infections.
Fichier principal
Vignette du fichier
art_10.1007_s11051-013-1595-4.pdf (723.79 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01243099 , version 1 (14-12-2015)

Licence

Paternité

Identifiants

Citer

Jasmina Vidic, Slavica Stankic, Francia Haque, Danica Ciric, Ronan Le Goffic, et al.. Selective antibacterial effects of mixed ZnMgO nanoparticles. Journal of Nanoparticle Research, 2013, 15 (5), pp.1595. ⟨10.1007/s11051-013-1595-4⟩. ⟨hal-01243099⟩
289 Consultations
160 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More