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Article Dans Une Revue Physical Chemistry Chemical Physics Année : 2013

Enhanced potassium selectivity in a bioinspired solid nanopore

Résumé

Biological ion channels present unique ionic properties. They can be highly permeable to ions, while selecting only one type of ions, without external energy supply. An important research field has been developed to transfer these properties to solid state nanoporous membranes in order to develop artificial biomimetic nanofilters. One of the promising ways to develop biomimetic structures is based on the direct insertion of the gramicidin A, i.e. an ionic channel, inside a nanopore. Experiments have recently proved the feasibility of such a hybrid membrane with very interesting results regarding the ionic selectivity. Here, we propose to interpret these experiments using theoretical molecular dynamic simulations which allow us to analyze more profoundly the structures of the proteins confined inside the nanopore and the relation between their conformation and the observed ionic properties.
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Dates et versions

hal-01241275 , version 1 (10-12-2015)

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Fabien Picaud, Sebastian Kraszewski, Christophe Ramseyer, Sebastien Balme, Philippe Dejardin, et al.. Enhanced potassium selectivity in a bioinspired solid nanopore. Physical Chemistry Chemical Physics, 2013, 15 (45), pp.19601-19607. ⟨10.1039/c3cp52123k⟩. ⟨hal-01241275⟩
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