Structural organisation of cationic dioctadecyldimethyammonium bromide monolayers in presence of hyaluronic acid - Archive ouverte HAL
Article Dans Une Revue European Biophysics Journal Année : 2009

Structural organisation of cationic dioctadecyldimethyammonium bromide monolayers in presence of hyaluronic acid

R. Ionov
  • Fonction : Auteur
A. El-Abed
  • Fonction : Auteur
Michel Goldmann

Résumé

Langmuir monolayers of dioctadecyldimethyammonium bromide and its interaction with the natural mucopolysaccharide hyaluronic acid are studied using thermodynamic methods and X-ray diffraction at grazing incidence. The 2D crystalline lattice parameters of different phases are determined. The monolayer compressibility, the linear crystalline compressibility components and the thermoelastic expansion coefficient are evaluated. The biopolymer stabilises the monolayer structural properties, increases the collapse pressure and the correlation length of the 2D crystalline domains. The results show that this lipid has a potential for developing of stabilised drug delivery systems of anionic biopolymers like hyaluronic acid, oligomers and genes.

Dates et versions

hal-01239044 , version 1 (07-12-2015)

Identifiants

Citer

R. Ionov, A. El-Abed, Michel Goldmann. Structural organisation of cationic dioctadecyldimethyammonium bromide monolayers in presence of hyaluronic acid. European Biophysics Journal, 2009, 38 (2), pp.229-235. ⟨10.1007/s00249-008-0374-0⟩. ⟨hal-01239044⟩
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