Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines - Archive ouverte HAL Access content directly
Journal Articles MedChemComm Year : 2010

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Pascal Pigeon
Siden Top
  • Function : Correspondent author
  • PersonId : 978929

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Anne Vessières
Elisabeth A. Hillard
Gérard Jaouen

Abstract

A series of new 1-[di-(4-R-phenyl)-methylidenyl)]-[3]ferrocenophanes, where R = OH, NH2, NHAc, and the phenyl substitution is mixed or identical, are highly antiproliferative against MDA-MB-231 and PC-3 cancer cells, with IC50 values ranging from 0 05-5 6 mu M on MDA-M B-231 and 0 02-12 5 mu M on PC-3
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Dates and versions

hal-01230393 , version 1 (17-03-2016)

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Meral Görmen, Pascal Pigeon, Siden Top, Anne Vessières, Marie-Aude Plamont, et al.. Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines. MedChemComm, 2010, 1 (2), pp.149-151. ⟨10.1039/c0md00026d⟩. ⟨hal-01230393⟩
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