Article Dans Une Revue Trends in Biochemical Sciences Année : 2015

Gene dosage imbalances: action, reaction, and models.

Résumé

Single-gene deletions, duplications, and misregulation, as well as aneuploidy, can lead to stoichiometric imbalances within macromolecular complexes and cellular networks, causing their malfunction. Such alterations can be responsible for inherited or somatic genetic disorders including Mendelian diseases, aneuploid syndromes, and cancer. We review the effects of gene dosage alterations at the transcriptomic and proteomic levels, and the various responses of the cell to counteract their effects. Furthermore, we explore several biochemical models and ideas that can provide the rationale for treatments modulating the effects of gene dosage imbalances.

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Dates et versions

hal-01226425 , version 1 (09-11-2015)

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Reiner A Veitia, Marie Claude Potier. Gene dosage imbalances: action, reaction, and models.. Trends in Biochemical Sciences, 2015, 40 (6), pp.309-17. ⟨10.1016/j.tibs.2015.03.011⟩. ⟨hal-01226425⟩
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