Flame ignition, stabilization and extinction or pollutant predictions are crucial issues in Large Eddy Simulations (LES) of turbulent combustion. These phenomena are strongly influenced by complex chemical effects. Unfortunately, despite the rapid increase in computational power, performing turbulent simulations of industrial configurations including detailed chemical mechanisms will still remain out of reach for a long time. This article proposes a review of commonly-used approaches to address fluid/chemistry interactions at a reduced computational cost. Several chemistry modeling routes are first examined with a focus on tabulated chemistry techniques. The problem of coupling chemistry with LES is considered in a second step. Examples of turbulent combustion simulations are presented in the final part of the article. Three LES applications are analyzed: a lean swirled combustor, a non-adiabatic turbulent stratified flame and a combustion chamber where internal recirculations promote the dilution of fresh gases by burnt gases.