The aim of the study is to evaluate driving performance during monotonous task depending on Blood Alcohol Concentration (BAC), and driving experience. Assuming that, during monotonous driving task, performance should be impaired with a BAC increased. This impairment should be more pronounced for Young Novice Drivers (YND) than for Young Experienced Drivers (YED). YND (18 years, less than two months of driving license) and YED (21 years, 3 years of driving license) were invited to participate in three simulated driving sessions separated by a minimum of 24 hours in which BACs were randomly manipulated (0.0, 0.2 and 0.5 g/L). Every experimental session took place during postprandial period at the circadian nadir. Task was to drive on a simulated typical highway road during 45 min and to maintain a steady speed (110 Km/h) and stable position on the right lane. Variation in lane position and speed were chosen as the primary outcome variables because they have been shown to be sensitive in this kind of task. Before and after each driving session, participants responded to Thayer scale (alertness and tension estimation). After each driving session they also responded to an adaptation of the NASA-TLX (NASA-Task Load Index). Speed, lane position of vehicle and Electro Dermal Activity (EDA) of the drivers were continuously recorded. Drivingperformance data were analyzed for 8 temporal intervals of 5 min (because we excluded the first temporal interval of 5 min). Results from the self-report scales showed interactions and significant differences between the two groups. No difference was observed as a function of BAC for the YND but time-on-task effect was observed. Conversely, YED's estimations showed a variation of subjective alertness, arousal and effort depending on the Alcoholic conditions. Concerning driving performance, triple interactions was obtained between temporal interval*Alcohol*Group. Both groups of young drivers appear to be sensitive on time-on-task effect and alcohol condition for different indicators used. Overall, for standard deviation of lane position YND seemed to show perturbations for the highest BAC conditions (0.5 g/l) while the YED seemed more disrupted linearly by the increase of BAC conditions (0.0; 0.2 and 0.5 g/l) and time-on-task effect. EDA show also differences. As expected, performance impaired with an increased BAC, and the first effect of fatigue appears in temporal window between 15 to 30 min for different indicators and for both groups. This decrease of performance with alcohol was already present for BAC 0.2 for both groups.