Anti-inflammatory properties of [i]Streptococcus salivarius[/i], a commensal bacterium of the oral cavity and digestive tract - Archive ouverte HAL Access content directly
Journal Articles Applied and Environmental Microbiology Year : 2014

Anti-inflammatory properties of [i]Streptococcus salivarius[/i], a commensal bacterium of the oral cavity and digestive tract

Abstract

Streptococcus salivarius is one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. The anti-inflammatory potential of S. salivarius was first evaluated in vitro on human intestinal epithelial cells and human peripheral blood mononuclear cells. We show that live S. salivarius strains inhibited in vitro the activation of the NF-κB pathway on intestinal epithelial cells. We also demonstrate that the live S. salivarius JIM8772 strain significantly inhibited inflammation in severe and moderate colitis mouse models. These in vitro and in vivo anti-inflammatory properties were not found with heat-killed S. salivarius, suggesting a protective response exclusively with metabolically active bacteria.
Fichier principal
Vignette du fichier
Appl. Environ. Microbiol.-2014-Kaci-928-34_1.pdf (920.6 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01204328 , version 1 (28-05-2020)

Identifiers

Cite

Ghalia Kaci, Denise Goudercourt, Véronique Dennin, Bruno Pot, Joel Dore, et al.. Anti-inflammatory properties of [i]Streptococcus salivarius[/i], a commensal bacterium of the oral cavity and digestive tract. Applied and Environmental Microbiology, 2014, 80 (3), pp.928-934. ⟨10.1128/AEM.03133-13⟩. ⟨hal-01204328⟩
94 View
48 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More