Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2012

Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice

Résumé

Regular consumption of food enriched in omega3 polyunsaturated fatty acids (oméga3 PUFAs) has been shown to reduce risk of cognitive decline in elderly, and possibly development of Alzheimer's disease. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the most likely active components of oméga3-rich PUFAs diets in the brain. We therefore hypothesized that exposing mice to a DHA and EPA enriched diet may reduce neuroinflammation and protect against memory impairment in aged mice. For this purpose, mice were exposed to a control diet throughout life and were further submitted to a diet enriched in EPA and DHA during 2 additional months. Cytokine expression together with a thorough analysis of astrocytes morphology assessed by a 3D reconstruction was measured in the hippocampus of young (3-month-old) and aged (22-month-old) mice. In addition, the effects of EPA and DHA on spatial memory and associated Fos activation in the hippocampus were assessed. We showed that a 2-month EPA/DHA treatment increased these long-chain oméga3 PUFAs in the brain, prevented cytokines expression and astrocytes morphology changes in the hippocampus and restored spatial memory deficits and Fos-associated activation in the hippocampus of aged mice. Collectively, these data indicated that diet-induced accumulation of EPA and DHA in the brain protects against neuroinflammation and cognitive impairment linked to aging, further reinforcing the idea that increased EPA and DHA intake may provide protection to the brain of aged subjects.
Fichier principal
Vignette du fichier
publi_4797_{BF2627A1-20A4-4BE9-86B9-B32884793DDA}.pdf (2 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01191175 , version 1 (01-09-2015)

Identifiants

Citer

Virginie Labrousse, Agnès Nadjar, Corinne Joffre, Laurence Costes, Agnès Aubert, et al.. Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. PLoS ONE, 2012, 7 (5), 13 p. ⟨10.1371/journal.pone.0036861⟩. ⟨hal-01191175⟩
98 Consultations
96 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More